Analysis Between Preoperative NLR,PLR And Clinicopathological Characteristics In Patients With PTC

Objective: This study aimed to investigate the potential association of preoperative blood neutrophil-to-lymphocyte ratio(NLR)and platelet-tolymphocyte ratio(PLR),with clinicopathological characteristics of papillary thyroid carcinoma(PTC).And then found the clinical value of NLR,PLR for PTC.Methods: A retrospective analysis was conducted on the clinical pathological data of 238 patients with PTC who were admitted to Hebei General Hospital gland surgery from January 2014 to December 2015.The Receiver Operating Characteristic(ROC)curve was used to analyze the value of NLR and PLR to identify the risk of tumor recurrence and to obtain the best cut-off value.And then SPSS 21 statistical software was used to analyze the relationship between NLR,PLR and clinicopathological characteristics(such as gender,age,tumor diameter,tumor multifocal,lymph node metastasis or not,whether with Hashimoto's thyroiditis).P<0.05 was considered statistically significant difference.Results: Among the 238 patients with PTC,there was significant differences in the male,tumor diameter>1cm,lymph node metastasis and without Hashimoto's thyroiditis had a higher level of NLR(NLR>2.00;P<0.05).And there was significant differences in the female,tumor diameter>1cm and lymph node metastasis had a higher level of PLR(PLR>150.00;P<0.05).Logistic multivariate regression analysis showed that tumor size,lymph node metastasis and whether with HT were the independent influential factors of preoperative NLR(P<0.05).And gender,tumor size and lymph node metastasis were the independent influential factors of preoperative PLR(P<0.05).Conclusions:1.The higher preoperative NLR and PLR values in PTC patients suggest cervical lymph node metastasis.2.The best cut-off values of preoperative NLR and PLR for clinical value of PTC were 2.00,150.00.