| Part one Retrospective analysis of 524 elderly patients with skin tumorsObjective:Analyze the incidence and clinical characteristics of senile skin tumors in order to increase the clinical diagnosis rate and early treatment of cancer patients.Method:A retrospective analysis was performed on 524 elderly patients(60 years old and older)who were confirmed to be skin tumors by dermatological examination in our hospital from January 2015 to November2017.The SPSS 21.0 software package and Excel 2003 were used for data processing.The rate of comparison was analyzed using chi-square test.Normal distribution data were examined by t test and rank sum test was used for non normal distribution data.P<0.05 was statistically significant.Result:1 In this group of skin tumor cases,the ratio of benign skin tumors was not statistically significant between men and women(x~2=2.09,P>0.05).There was no significant difference in the ratio of malignant skin tumors between men and women(x~2=0.05,P>0.05).There was a statistically significant difference between men and women with precancerous lesions or rates of borderline benign and malignant tumors(x~2=5.899,P<0.05).2 The largest number of skin tumors diagnosed by pathology in this group of patients was the following(the top 5 of the sample ranked high to low):180 cases of seborrheic keratosis(SK)and 56 cases of basal cell carcinoma(BCC).There were 42 cases of nevocytic nevus,40 warty dyskeratoma,and 32 cases of actinic keratosis(AK).3 According to the new age,the subgroups were optimized.There were 398(60-74 years old),122(75-89 years),and 4(?90years)patients.There were significant differences in skin tumors of different age groups(P<0.05).4 The tumors with different characteristics in different parts showed statistical differences by chi-square test(x~2=40.358,P<0.01).Part two Study on T lymphocyte subsets of peripheral blood in elderly patients with malignant skin tumorsObjective:Study the changes of T-lymphocyte subsets in elderly skin cancer patients and find the immune status of this group of people.Method:We used flow cytometry to detect peripheral blood T-lymphocyte subsets in elderly patients diagnosed with cutaneous malignancy from June 2017 to January 2018 in our hospital.SPSS 21.0statistical software package and Excel 2003 software were used for statistical analysis of experimental data,normal distribution measurement data using mean±standard deviation,non-normal distribution data with a median(interquartile range),positive The statometric data were compared using the independent sample t test,and the non-normally distributed measurement data were tested with the rank sum test.?=0.05 for the test level,P<0.05 was statistically significant.Result:In the peripheral blood T lymphocyte subsets of the two groups of p atients,the percentage of CD3~+(%)in the experimental group was(68.48±10.76),the control group was(71.49±7.05),the two groups had no statistical difference(t=1.28,P>0.05),and the average number of CD4~+percent(%)in the experimental group(37.86±10.43)was less than the control group.The number(42.43±5.49),the two groups were statistically different(t=2.16,P=0.03),the percentage of CD8~+(%)in the experimental group was(28.57±9.80),the control group was(27±6.21),and there was no statistical difference between the two groups(t=0.741,P>0.05);the two group CD4~+/CD8~+,the experimental group 1.38(1.01),and the control group 1.55(0.61),There was no statistical difference between the two groups(P>0.05).Compared with the count(*109/L),0.85(0.64)of the CD3~+T cell count group was less than 1.26(0.59)in the control group,and there was a significant difference between the two groups(P<0.01);the 0.46(0.40)of the CD4+T cell count group was 0.75(0.41),and the two groups had significant statistical difference(P<0.01);the CD8~+T cell count was compared.The experimental group 0.32(0.19)was less than the control group 0.49(0.33),the two groups had statistical difference(P<0.05).Conclusions:1.In this group of patients,there was no statistically significant difference in the incidence of benign and malignant skin tumors between men and women.The ratio of precancerous lesions or borderline tumors for benign or malignant disease was 0.4:1.The difference was statistically significant.The incidence of females was higher than that of men.2.The tumors with different characteristics in different stages of old age are statistically different.Specifically,there are more elderly skin tumor patients aged 60-74 years older than 75-89 years old and 90-year old patients with two phases.3.The tumors with different characteristics in different parts have statistical differences,while the head and neck are the good sites for skin tumors.4.Among the peripheral blood T-lymphocyte subsets,the CD3~+T cell count,CD4~+T cell count,CD4~+T cell count,and CD8~+T cell count in patients with skin cancer were all less than those in the benign control group,suggesting that the skin was malignant.The immune function of cancer patients has been reduced to varying degrees. |
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