Efficay And Safety Of Submucoal Tunneling Endoscopic Resection For Upper Gastrointestinal Submucosal Tumors And Exploration For Influencing Factors

Background: Submucosal tunneling endoscopic resection(STER)has emerged as a feasible technique for resecting upper gastrointestinal(GI)tract submucosal tumors(SMTs)through natural orifice transluminal endoscopic surgery.STER reduces the risk of postoperative perforation and abdominal infections,and promotes rapid wound healing.The aim of this meta-analysis was to evaluate the safety and efficacy of STER for small(? 3.5 cm)upper GI SMTs and explore the potential factors influencing STER's efficacy and complication rate.Methods: Comprehensive literature searches were performed to find studies on STER for removal of SMTs.Several English-language databases were searched,including MEDLINE(through Pub Med),EMBASE,and Cochrane Library for the period May2010-May 2016.The medical terms “submucosal tunneling endoscopic resection or STER,” “upper gastrointestinal,” and “submucosal tumors” were used in the search.The primary outcome measures were the pooled estimates of the complete resection and en bloc resection rates.The secondary outcome measure was the pooled estimate of complications.Result: Twelve studies including 397 patients and 430 lesions were identified.The pooled estimate of the complete resection rate was 98.1%(95% confidence interval [CI]:95.9%-99.2%).The pooled estimate of en bloc resection was 94.9%(95% CI:91.1%-97.1%).The pooled estimate of gas-related complications such as pneumoperitoneum and subcutaneous emphysema was 21.5%(95% CI: 13.2%-33.1%).The pooled estimate of inflammation-related complications including pleural and abdominal effusion was 8.4%(95% CI: 5.6%-12.3%).Gas-related complications occurred more frequently in the esophagogastric junction than in the stomach.In addition,the pooled estimate of delayed bleeding was 2.2%(95% CI: 1.0%-4.7%).Conclusion: STER appeared to be an extremely effective technique for removing upper GI SMTs originating from the muscularis propria layer.In addition,the very low rate of complications also shows the safety of this technique.Tumor size,infiltration depth,and location may influence the complication rates.