Expression Of XPD In The Gastric Cancer Tissue And Its Relationship With Prognosis

Objective: Xeroderma Pigmentosum Complementation Group D(XPD)was identified to be differential expression in solid tumor tissues,adjacent normal tissues and normal health tissues,and may be involved in the tumorigenesis,progression and prognosis.Our study investigated the expression of XPD in gastric cancer tissues and normal health tissues,and analyze the correlation between the expression of XPD and clinical pathological parameters and prognosis of cancer patients.Method: The protein expression profiles of XPD were studied in 38 early gastric cancer tissues,87 advanced gastric cancer tissues and 48 gastric mucosa tissues of superficial gastritis(as normal health tissues)by using immunohistochemistry.We explored the relation between the expression of XPD in gastric cancer tissues and clinical pathological parameters(age,gender,tumor size,T-stage,N-stage,TNM stage and Borrmann classification).In combination with follow-up data,we conducted the survival analysis of patients by using Kaplan-Meier analysis and Cox proportional hazards regression models.Results: The expression of XPD was higher level in gastric cancer tissues than normal health tissues.There was no statistically significant difference with XPD in gastric cancer tissues within age,gender,T-stage,N-stage,TNM stage and Borrmann classification(P>0.05).We revealed that there was no statistically significant difference between high and low level expressions of XPD in overall survival rates in gastric cancer patients by using Kaplan-Meier curve.Univariate analysis confirmed that age,tumor size,TNM stage and Borrmann classification affected the overall survival of patients.Multivariate analysis showed that TNM stage(P=0.012)was the strongest independent prognostic factors for OS.Conclusion:Our study revealed that the expression of XPD in gastric cancer tissues higher than the normal health tissues.We concluded that XPD may be involved in the tumorigenesis and progression in gastric cancer.The expression of XPD is not related to the clinical pathological features,which revealed that there was no connection between the expression of XPD and tumor biological behaviors.The XPD was not an independent prognostic factor for the overall survival of gastric cancer patients.It could not yet serve as a biomarker for predicting the prognosis of patients with gastric cancer.