Comparison The Treatment Effects Of Surgical Resection And Non-surgical Resection For Barcelona Clinic Liver Cancer Stage B And C

Objective:To compare clinical results of surgical resection and non surgical resection for patients with hepatocellular carcinoma in BCLC stage B and C.Methods:From June 2011 to June 2013,the clinical data of Tongji hospital hepatic surgery diagnosis and treatment of 52 cases in BCLC stage B and 58 cases in BCLC stage C were comparative analysised.24 cases of BCLC stage B underwent surgical resection and 28 cases of BCLC stage B underwent non-surgical treatment in which included TACE,microwave ablation,etc.32 cases in BCLC stage C underwent surgical resection and 26 cases in BCLC stage C underwent non-surgical treatment.Results:All patients followed up to January 2017.In BCLC stage B,the surgical group median survival time was 28(10.4)months and the non-surgical group median survival time was 17(7.9)months,the 1?2?3-year cumulative survival rates 0f BCLC stage B in surgical resection and non-surgical treatment were 83.3%?66.7%?50.0% and 57.1%?42.9%?25.0%,respectively;and the Log-Rank test result show that the surgical and non-surgical group survival difference had no statistical significance(P=0.159).The cox results of single factor and multiple factors analysis are showed that age>50 years,MELD >9 scores and cirrhosis are independent risk factors for HCC after treatment,and the different methods of treatment are not its risk factors.The median survival time in surgical resection group and non-surgical resection group in BCLC stage C were 12.0(4.8)months and 5.0(0.5)months,and the overall survival rate of 1?2?3-years of surgical and non-surgical treatment were 50.0%?43.8%?40.6% and 7.7%?0.0%?0.0%,and the Log-Rank test rusult shows that the surgical and non-surgical group difference was statistically significant(P <0.01).The cox results of single factor and multiple factors analysis are showed that alkaline phosphatase?100IU/L,portal vein tomor thrombus and the methods of treatment are independent risk factors for patients with BCLC stage C.The median survival time in the surgical group of branch portal vein tumor thrombus compared with the main portal vein tumor thrombus is 11.0(1.8)and 4.0(1.6)months,the Log-Rank test showed that the survival difference between branch portal vein tomor thrombus and main portal vein tumor thrombus was statistically significant(P<0.01).Conclusions: The treatment effects of surgical resection and non-surgical therapeutic effect without significant difference for patients with BCLC stage B,however the treatment effects of surgical resection for patients with BCLC stage C is significant better than that of non-surgical treatment,especially the prognosis of branch of portal vein tumor thrombus is superior to the prognosis of main portal vein tumor thrombus.