Association Of NOD1 Gene Polymorphisms With The Susceptibility For Lung Cancer

Objectives As one of pattern recognition receptors(PRRs),NOD1 is an important factor to effect on the development of lung cancer.Genetic polymorphisms of NOD1 affect the susceptibility of variants of cancers.However,there are few reports related to lung cancer.This study aims to explore the associations of genetic variants(rs2075819 A>G and rs2075820 G>A)in NOD1 gene with the susceptibility for lung cancer.Methods A total of 706 lung cancer patients and 706 healthy people were included in this case-control study.Cases with non-small cell lung cancer were collected from Tangshan Gongren Hospital and Tangshan People's Hospital from January 2008 to December 2014.The controls were randomly selected from cancer-free population from the community conducted in the same region during the same period when patients were recruited.The genotypes of NOD1 rs2075819 A>G and rs2075820 G>A were determined by polymerase chain reaction-based restriction fragment length polymorphism(PCRRFLP).The OR and 95%CI were estimated by logistic regression to evaluate the associations of NOD1 rs2075819 A>G and rs2075820 G>A variants with the risk of lung cancer.Results Compared with NOD1 rs2075819 AA genotype carriers,AG genotype carriers had a significant decreased risk of developing NSCLC(P = 0.044)with OR(95%CI)of 0.79(0.63-0.99).When stratified by age for rs2075819,AG genotype carriers had a decreased risk only among youngers(age ? 60)(P = 0.018)with OR(95%CI)of 0.69(0.51-0.94).When stratified by smoking status for rs2075819,AG genotype carriers had a decreased risk among non-smokers(P = 0.037)with OR(95%CI)of 0.74(0.56-0.98).There was no significant difference in NOD1 rs2075820 genotype distribution between lung cancer patients and controls.Conclusions NOD1 rs2075819 A>G polymorphism contributes to the risk of NSCLC in Chinese population.NOD1 rs2075820 G>A polymorphism is not associated with the risk of lung cancer.