| Objective:To study and observe the change status of peripheral blood T,B lymphocyte subsets and Th1 type cytokines of patients with cirrhosis caused by hepatitis B.Methods:65 patients with cirrhosis caused by hepatitis B in our hospital from June 2015 to October 2016 were selected as the observation group,65 healthy persons with physical examination at the same time were selected as the control group,then the peripheral blood T,B lymphocyte subsets and Th1 type cytokines levels of two groups were detected and compared,and peripheral blood T,B lymphocyte subsets and Th1 type cytokines levels of observation group with different Child-pugh classifications and whether or not with splenomegaly were compared too.Results:The peripheral blood T lymphocyte subsets(CD3+,CD4+,CD3+CD4+and CD4/CD8)and CD5+,serum IL-2 levels of observation group were respectively(57.20±5.15)%,(35.35±3.60)%,(28.98±2.81)%,(1.23±0.12),(63.23±5.75)% and(4.31±0.41)ng/ml,they were all lower than(64.24±5.78)%,(42.56±4.18)%,(37.35±3.95)%,(1.78±0.21),(70.45±6.38)% and(6.20±0.63)ng/ml of control group,other peripheral blood B lymphocyte subsets(CD20+,CD40L+ and CD5+CD19+)and Th1 cytokines(IFN-?,TGF-? and TNF-?)were respectively(6.84±0.45)%,(9.45±0.63)%,(5.72±0.46)%,(105.64±10.72)ng/L,(276.72±34.75)pg/ml and(1.63±0.24)ng/ml,they were all higher than(3.31±0.25)%,(5.25±0.37)%,(2.43±0.22)%,(80.25±6.34)ng/L,(169.89±20.34)pg/ml and(0.83±0.13)ng/ml of control group,and those indexes? detection results of observation group with different Child-pugh classifications and whether or not with splenomegaly had obvious differences,all P<0.05.Conclusion:The peripheral blood T,B lymphocyte subsets and Th1 type cytokines of patients with cirrhosis caused by hepatitis B show obviously abnormal expression state,and those indexes all have certain detection value for the Child-pugh classifications and splenomegaly of patients with cirrhosis caused by hepatitis B. |
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