FoxA1 And CK7 Expression In Esophageal Squamous Cell Carcinoma And Its Prognostic Significance

Objective: To explore the relationship between the expression level of CK7 and FoxA1 in ESCC patients with the clinicopathological features and prognosis,and to explore the relationship between CK7 and FoxA1.Methods: Making tissue microarray using esophageal ulcer type squamous cell carcinoma samples;using immunohistochemistry to detect CK7 and FoxA1 expression level;statistical analysis of the relationship between the expression of FoxA1 and CK7,analysing the relationship between the expression of FoxA1 and CK7 with the ESCC patients' clinicopathological features and prognosis.Results: In the 610 ESCC specimens,positive staining of CK7 was59/594(9.93%).CK7 expression was correlated with ESCC differentiation(P=0.006).The expression of CK7 is associated with poor overall survival(OS)of ESCC patients(P=0.0498).FoxA1 positive staining was 180/586(30.72%).FoxA1 expression correlates with differentiation(P<0.0001)and vascular invasion status(P=0.016)of ESCC.FoxA1 expression was non-independently correlated with poor prognosis of OS in ESCC patients(P=0.1198),but correlated with the prognosis of ESCC patients in some specific pathological characteristics,such as age,tumor location,and lymph node metastasis or not.Correlation analysis between the CK7 and FoxA1 expression was positive(P<0.0001).Conclusions: FoxA1 expression was positive correlated with CK7 expression.CK7 expression is an independent prognostic factor for ESCC,and FoxA1 is a non-independent prognostic factor.CK7 and its upstream factor FoxA1 both can be used as potential targets for ESCC therapy.