Risk Factors Of Intracranial Infection After Ventriculo-Peritoneal Shunt For Hydrocephalus

Objective:To analyze the risk factors of intracranial infection(ICI)after ventriculo-peritoneal shunt(VPS)to provide some theoretical basis for clinical prevention and improvement of prognosis of patients.Methods:The clinical data of 403 patients undergoing ventriculo-peritoneal shunt(VPS)from January 2013 to December 2016 for neurosurgery department in our hospital were collected and screened by inclusion criteria and exclusion criteria.382 patients were enrolled,according to whether postoperative intracranial infection occurred,all patients were divided into two groups,infection group and uninfected group.The data of the two groups were compared.Univariate analysis was performed using Chi-square test(Fisher exact analysis).Multivariate analysis was performed using binary logistic regression analysis to screen out the independent risk factors for ICI after VPS.Result:Of the 382 patients,228 were males and 154 were females.The age ranged from 18 to 84 years,with an average of 56.16±14.04 years.There were 23 in the infected group and 359 in the non-infected group.Risk factors associated with postoperative intracranial infection by univariate analysis were: GCS<9points(P=0.001),post brain surgery(P=0.043),postoperative plugging(P<0.001).A multivariate logistic regression analysis was performed on the three indicators with statistical significance in univariate analysis.Finally,independent risk factors for intracranial infection after VP shunting were preoperative GCS(OR=3.363,P=0.01,95%CI:1.350-9.145)and plugging(OR=8.195,P<0.001,2.939-24.513).Conclusion:Preoperative GCS(<9points)and postoperative plugging are independent risk factors for ICI after VPS.Taking corresponding preventive measures against the above factors can reduce the incidence of postoperative ICI.