Clinical Research Of Shehuang Paste Combined With Biejiajian Pills In Treatment Of Refractory Cirrhosis Ascites

Objective:In this study,we hope that by applying SheHuang Paste and Biejiiajian Pills,we can observe its curative effect and provide new treatment plan for the refractory cirrhosis ascites.and improve the effection of Chinese medicine treatment in refractory cirrhosis ascites.Providing a strong evidence based medical data,and carry forward the Chinese medicine culture.Methods:Sixty patients with refractory cirrhosis ascites were collected from the Department of Hepatology,Shenzhen Hospital of Traditional Chinese Medicine.The patients were divided into treatment group and control group by random number table method,with 30 cases in each group.The control group was treated with western medicine.The treatment group was treated with the western medicine and combined with SheHuang Paste and Biejiajian Pills.Both of the two groups were treated for 4 weeks.Body weight,abdominal circumference,24 h urine output,liver functions,renal functions,hemodynamics,NO,endotoxin,endothelin and abdominal ultrasound were observed before and after treatment,for the clinical efficacy of SheHuang Paste combined with Biejiajian Pills.Result:1、After treatment,the patients in control group the scores of breathless,rib pain,abdominal distension,dry mouth were significantly decreased(P <0.01).The anepithymia and dullness of the face had no significant improvement(P> 0.05).After treatment,the patients in treatment group breathless,rib pain,abdominal distension,anepithymia,dull mouth and dullness of the face significant improvement(P <0.01).Compared with the control group,the treatment group showed a significant improvement in the rib pain,abdominal distension,anepithymia,dullness of the face and breathless compared with the control group(P <0.01),while the dry mouth had no significant changes(P> 0.05).2、The ALT,AST,GGT,TB and ALB in the control group were statistically different than those before treatment(P <0.01).After treatment,the patients in the treatment group had lower ALT,AST,GGT,TB and higer ALB before treatment(P <0.01).Compared with the control group,the TB after treatment in the treatment group was lower than that in the control group(P<0.05),while the levels of ALT,AST,GGT and ALB were not statistically different(P> 0.05).3、There was no significant difference in the diameter of the portal vein and splenic vein after treatment in the control group(P> 0.05).After treatment,the diameter of portal vein and splenic vein of patients in treatment group were smaller than those before treatment(P <0.01).Compared with the control group,the treatment group received better effection of portal vein and splenic vein diameter than the control group(P <0.01).4、In the control group,the 24 hours urinary volume increased after treatment(P <0.05).After treatment,the body weight,abdominal circumference decreased and urine output increased in treatment group(P <0.01).Compared with the control group,the improvement of abdominal circumference and 24 h urine volume in treatment group was better than that in control group(P <0.01).5、The control group had better UREA(P <0.01)and no significant difference between creatinine CREA and coagulation(PT)(P> 0.05).The patients in treatment group had better creatinine(CREA)and urea(UREA)afer treatment than those before treatment(P <0.01)and no significant difference in coagulation(PT)(P> 0.05).Compared with the control group,the treatment group improved the treatment of creatinine(CREA)and urea(UREA)better than the control group(P <0.01).6、The control group had better NO,ET and endotoxin after treatment(P <0.01 or P <0.05).After treatment,the treatment group had better NO,ET and endotoxin than before treatment(P <0.01).Compared with the control group,the improvement of NO,ET and endotoxin in the treatment group was better than that in the control group(P <0.01).7、The two groups by the efficiency of redit analysis,the treatment group 66.6% efficiency,P <0.05,with statistical significance.No ascites in the control group regression I,the overall efficacy of the treatment group was better than the control group.8、 Multivariate logistic regression analysis,the forward method of screening variables,the introduction of variable test level α = 0.05,the OR value of CREA and treatment group were 1.15(1.06-1.25)and 178.34(8.08-3937.20),indicating creatinine ascending High and ineffective treatment can increase the risk of refractory ascites.Conclusion:In the clinical study of refractory ascites,the liver functions,renal functions and ascites were improved and better than that of the control group,which can improve the symptoms of the patients and have certain preventive liver Renal syndrome effect.