The Relationship Between The Clinical Features And Prognosis In Triple-Negative Breast Cancer

【Objective】To study the relationship between the clinical features and prognosis in triple-negative breast cancer(TNBC).【Methods】Retrospective analysis of 190 cases of breast cancer patients treated at the First Affiliated Hospital of Soochow University from June 2012 to December 2014 was conducted.All of the patients had definite postoperative pathology,immunohistochemical test suggested triple negative,and all of them accepted the adjuvant chemotherapy regimens of anthracycline and cyclophamine followed by paclitaxel.The clinical characteristics of the patients,such as age,body mass index,tumor size,lymph node metastasis,average relative dose intensity,survival status and the other were reviewed and collected.SPSS17.0 statistical software was used for analysis.Logistic regression model was conducted for single factor correlation analysis.The chi-square test was used to compare the frequencies.Kaplan-Meier method was used to analyze disease-free survival and overall survival.Cox proportional risk model was used in multivariate analysis,and P<0.05 was considered statistically significant.【Results】Among the 190 patients with TNBC,the median follow-up time was 45(22-66)months.There were 53 cases of recurrence or metastasis,of which there were 42 cases occurred within 3 years.The median disease free survival(DFS)time was 18 months.Of all patients,21 cases were fatal,and the median overall survival(OS)time was 36 months.Single factor analysis showed that the factors influencing disease-free survival,including body mass index,tumor size,lymph node status,clinical stage,histological grade,and dose intensity.Factors affecting the overall survival rate were body mass index,tumor size,lymph node status and clinical stages.Cox multivariate analysis showed that lymph node status and pathological type were independent risk factors for the prognosis of patients with triple-negative breast cancer.The average relative dose intensity(ARDI)was between 0.67 and 1.11,with the median ARDI of 0.83.Then,all of the patients were divided into two groups according to ARDI,namely low-dose group(ARDI < 0.85)and high-dose group(ARDI ≥0.85).The PFS rates of 1 year,2 years and 3 years of low dose group and high dose group were 92%vs99%,79%vs93%,71%vs86%respectively.The difference between the two groups was statistically significant(p < 0.05).【Conclusion】1.The recurrence and metastasis of TNBC frequently occurred within 3 years after operation.2.Body mass index,tumor size,clinical stage,histological grade,and especially lymph node status are of great importance to prognosis of patients.3.The dose intensity was correlated with the prognosis of patients,high dose intensity chemotherapy can prolong the disease free survival and reduce the risk of recurrence and metastasis.