The Study On Correlation Between Skeletal Muscle Index Of L3 Vertebral Body And Malnutrition In Patients With Advanced Lung Cancer

Objective: To determine whether it can be used as an independent predictor of malnutrition in patients with advanced lung cancer.Methods: A retrospective analysis of patients with advanced lung cancer who were treated by internal medicine at the Cancer Center of the First Hospital of Jilin University from January 2017 to July 2017 was performed.The relevant data were analyzed.Using abdominal CT analysis L3 skeletal muscle index and patient PG-SGA score,BMI(body mass index)and serological indicators were analyzed.According to the PG-SGA scores,severe malnutrition group(?9 points),mild to moderate malnutrition group(?3 points and ?8),and no malnutrition group(?2 points)were divided into three groups.difference.Pearson correlation analysis was performed between skeletal muscle index and PG-SGA score,BMI,and laboratory test indicators.Univariate and multivariate Logistic regression analysis was performed on the related influencing factors of malnutrition to identify the risk of severe malnutrition and protective factors.Results: 1.In severe malnutrition group,there were 17 males and 13 females with an average age of(63.47±10.02)years.There were 24 males and 22 females with mild to moderate malnutrition.The average age was(60.35±9.23)years.There was no malnutrition group male.Cases,2 females,mean age(56.41 ± 9.76)years old.Severe malnutrition group,mild to moderate malnutrition group and no malnutrition group,the difference in age of patients was statistically significant.2.Patients with severe malnutrition and mild to moderate malnutrition had significantly lower PA than those without malnutrition,and patients with severe malnutrition,mild to moderate malnutrition,and no malnutrition had lower BMI but no significant difference..The BMI was(24.04±3.11)kg/m2,(23.76±2.58)kg/m2 and(22.51±3.33)kg/m2,respectively.The PA values were(4.79±0.99)mg/L,(5.12±0.67)mg/L,and(6.07±0.71)mg/L,respectively.The difference was statistically significant.The Alb malnutrition group was lower than the no malnutrition group,and Alb was(36.96±5.65)g/L,(39.56±4.92)g/L,and(38.88±2.68)g/L,respectively,but there was no statistical difference.The NLR severe malnutrition group was significantly higher than the non-malnutrition group,the difference was statistically significant,and there was no significant difference between the mild to moderate malnutrition group and the no malnutrition group.The NLR was(189.43±118.40),(179.52±121.25),and(157.94±53.98),respectively.The PLR was(189.43±118.40),(179.52±121.25),and(157.94±53.98),respectively,with no statistically significant difference in PLR.The BMI in patients with severe malnutrition and those with mild to moderate malnutrition were lower than those without malnutrition,but the results were not statistically different.The L3 skeletal muscle mass index in patients with severe malnutrition,mild to moderate malnutrition,and no malnutrition was(33.21 ± 6.25)cm2/m2,(45.64 ± 5.74)cm2/m2,and(49.48 ± 6.82)cm2/m2,respectively.The L3 skeletal muscle mass index of the severe malnutrition group was significantly lower than that of the non-malnutrition group.The difference was statistically significant.However,there was no significant difference between the patients with mild to moderate malnutrition and those without malnutrition.3.The Pearson correlation analysis was performed between the muscle mass index and the PG-SGA score and laboratory test results.The PG-SGA score was positively correlated with age(r=0.296)and NLR(r=0.248),but with L3 skeletal muscle mass index(r=-0.743),phase angle(r=-0.546),and PA(r=-0.373).),ALB(r =-0.205)BMI(r =-0.247)was negatively correlated(P <0.05 =).L3 skeletal muscle mass index was positively correlated with phase angle(r=0.754),PA(r=0.412),and ALB(r=0.341),but negatively correlated with age(r=-0.421)and NLR(r=-0.282).Related to PLR,BMI wireless.4.Multivariate analysis showed that L3 skeletal muscle index was an independent risk factor for severe malnutrition.Based on PG-SGA ?4 points as the cut-point value for diagnosing malnutrition,the receiver operating characteristic curve(ROC)was used to investigate the diagnostic value of L3 skeletal muscle index and traditional indicators of malnutrition.L3 skeletal muscle index,prealbumin,BMI,and NLR area were 0.874,0.733,0.526,and 0.341.L3 Skeletal muscle index had a good diagnostic effect.Conclusion: L3 skeletal muscle index,age,PA,and NLR were significantly different among patients with advanced nutritional lung cancer.L3 skeletal muscle index and PG-SGA are consistent in nutritional assessment of lung cancer patients.The L3 skeletal muscle index is an independent predictor of malnutrition in patients with advanced lung cancer.