Preoperative Neutrophil-to-Lymphocyte Ratio (NLR) Is Associated With Tumor Recurrence Following Curative Resection Of Pancreatic Adenocarcinoma

Objective:Objectives:To investigate correlations of post-operative recurrence of pancreatic malignant tumors and pre-operative Neutrophil to Lymphocyte Ratio(NLR).Methods:Retrospective analysis were performed for data from 114 patients those had pancreatoduodenectomy(PD)for pancreatic carcinomas(pancreatoduodenum,pancreatic body tail)at department of pancreatic surgery,NO.1 affiliated Hospital of Xinjiang Medical University during January,2015 to January,2017.Univariate analysis was performed using Log-rank for post-operative recurrence for pancreatic malignant tumors,median surviving time without tumor and clinicopathological features such as NLR.Results:Pre-operative routine blood test results are used to calculate pre-operative NLR values,and then NLR values were divided in 4 groups of NLR<1.66,1.66≤NLR<2.15,2.15≤NLR<2.93,NLR≥2.93 using quartiles.4 groups had median post-operative surviving times without tumor of 373 days,290 days,218 days and 190 days respectively.4 groups had post-operative survival rates without the tumor of 51.7%,39.3%,33.3%and20%respectively.The result shows that group of NLR≥2.93 had significantly lower surviving rate without a tumor compared to other 3 groups.This result indicates that NLR value may be associated to the post-operative recurrence of the tumor.Results of multivariate analysis show enhanced pre-operative peripheral NLR value,vascular invasion and poorly differentiation of the tumors are independent and drastic factors which effect post-operative recurrence for pancreatic cancer patients(p<0.05).Conclusion:Pre-operative peripheral blood NLR values may possess analytical and reference values on predictions of post-operative recurrence after surgical treatments of malignant pancreatic tumors.