The Application Of Random Mucosal Biopsy After The Transurethral Resection Of Bladder Tumor

Objective:To demonstrate the feasibility of random biopsy of bladder mucosal after TUR-Bt in patients with NMIBC,and to provide an appropriate value for clinical treatment of NMIBC.Materials and Methods:From February 2011 to June 2016,the data of bladder tumor and mucosal pathology in patients with NMIBC after TUR-Bt were collected retrospectively.The clinical data(age,tumor stage,nuclear grade,smoking history,etc.)of patients with NMIBC and the data of random biopsy of bladder mucosa were examined by X2 test.Results:In total of 230 patients,32 cases(13.9%)were found to have histological abnoemalities,including T1 in 3 cases(1.3%),Ta 1 cases(0.4%),CIS in 8 cases(3.5%),squamous metaplasia of bladder mucosa in 5 cases(2.2%)and untypical hyperplasia in 15 cases(6.5%).Besides,random mucosal biopsy was performed mainly in the bladder neck(7 cases)and trigonometry(12 cases).Among many factors,the pTl and Recurrent NMIBC are significantly correlated with random biopsy of bladder mucosa(P=0.032;P=0.05);Comparing the pathological stages of primary and recurrent NMIBC patients with random biopsy of bladder mucosa,there was a significant difference between the patients with recurrent bladder cancer and primary(P=0.038).Of the 73 patients with NMIBC in the pTa stage,59 cases were first onset,14 cases recurred,and the positive rate of mucosal random biopsy after primary TUR-Bt(3 cases,5.1%)was less than the positive rate of random biopsies after the recurrence of TUR-Bt(2 cases,14.3%).Conclusion:Random biopsy of bladder mucosa is recommended after TUR-Bt in pTl patients;Random biopsy of bladder mucosa is recommended for all recurrent NMIBC patients after TUR-Bt.Random biopsies are performed at least in the trigonometry or neck of the bladder,if the patient do not allow multiple random biopsies.