Mechanistic Study Of Salmonella Typhimurium YB1 Induced Inhibition Of Tumor Metastasis

Cancer is one of the most lethal diseases in humans from now,and tumor metastasis is often the leading cause of death.In order to treat tumor,people developed many methods,such as chemotherapy,radiation therapy,and tumor immunotherapy,which worth noting is that in recent years people use of engineering bacteria to treat tumor,also has obtained the good curative effect.Salmonella typhimurium is facultative anaerobic gram-negative bacteria,which has the potential ability of tumor targeting and destruction.What is more,it also has the advantage of simple genetic operations,so it is an ideal candidate strain can be used in engineering and cancer treatment.In our subject,YB1 of Salmonella typhimurium is a attenuated strain with strict anaerobic characteristics by genetic modification,which has excellent ability of tumor targeting and inhibiting tumor metastasis.Our lab found that YB1 have the ability to suppress a variety of tumor metastasis,and its ability of inhibiting tumor metastasis is dependent on the body's innate immune response,YB1 engineering bacteria stimulated the body to produce a strong inflammatory reaction,in the process of this,IFN gamma played a necessary but not sufficient role,in addition we find Ly6G positive cells and Ly6C positive cells under the stimulus of YB1 increased dramatically,which implies YB1 has played a vital role in the process of inhibiting tumor metastasis.