| Objectives:Selecting patients with advanced colorectal cancer as the research object,we prospectively analyzed the effect of traditional Chinese medicine on the survival and quality of life of patients with advanced colorectal cancer,and through univariate and multivariate analysis,the factors that influence the survival and prognosis were determined,which provided evidence-based evidence for clinical practice.Methods:By collecting 107 data of patients with advanced colorectal cancer from September 2015 to December 2016 in outpatient departments of Jiangsu Provincial Hospital of Traditional Chinese Medicine and the Department of Oncology of Jiangsu Provincial Hospital of Traditional Chinese Medicine and the Department of Oncology of Jiangsu Provincial Cancer Hospital,we divided these patients into 2 groups.52 cases who underwent Chinese medicine combined with Western medicine were experimental group and 55 cases who subjected to Western medicine alone were control group.Therapy in control group involved surgery,chemotherapy,radiotherapy,targeting and supportive treatment.Patients in experimental group received Western medicine treatment combined with traditional Chinese medicine group based on TCM syndrome dialectical treatment We followed the patients regularly until the end of December 2017.We observed the improvement of the survival and quality of life in the two groups and analyzed the age,gender,differentiation degree,primary tumor site,previous treatment methods,TCM treatment,and so on.The protective factors for the prognosis of advanced colorectal cancer.Results:(1)The baseline data of the two groups were balanced and feasible for the next step analysis.(2)The survival analysis showed that the OS of the experimental group was 820.14±51.39 days,the mOS was 780.00±31.31 days,the one-year survival rate was 94.2%,and the control group was 616.19±31.91 days,660.00±78.67 days,and 87.1%respectively.The median survival time of the experimental group was 120 days longer than that of the control group,with statistical differences.The PFS of the experimental group was 803.81±53.49 days,the mPFS was 1017.00±182.99 days,and the rate of progression-free in one year was 85.9%.The control group was 394.83±35.46 days,30.00±22.25 days,and 35.7%respectively,the median progression-free survival of the experimental group was 687 days longer than that of the control group,with statistically significant differences.(3)Cox regression analysis showed that in OS,the differences in TCM treatment,previous treatment methods,primary tumor sites,and pathological types were statistically significant(P<0.05),and the regression coefficient of TCM treatment for syndrome differentiation was-0.744<0.The risk RR is 0.475.In terms of PFS,the differences in the number of TCM treatment and metastases were statistically significant(P<0.05).The regression coefficient of TCM treatment was<0,and the corresponding regression coefficient B was-1.503<0,which was relatively dangerous.The degree of RR is 0.223,which can be concluded that TCM treatment is an independent protective factor for the prognosis of advanced colorectal cancer,and it highlights the advantages in the extension of the survival period.(4)In the quality of life scales,through 5 follow-up visits,Chinese medicine interventions can significantly improve gastrointestinal symptoms such as nausea and vomiting,diarrhea,constipation,fatigue,and anorexia from the second follow-up,and overall health,physical function,The role of functional areas has changed since the third follow-up,and the late differences are highly statistically significant,indicating that long-term adherence to traditional Chinese medicine has a good clinical benefit in improving the quality of life of cancers,(5)In the evaluation of safety,no significant hepatic or renal impairment occurred.The major adverse reactions were hematologic toxicity.The bone marrow suppression in Ⅱ-Ⅲ°andⅠ-Ⅱ° anemia were more common and there was no statistical difference between the two groups(P>0.05).Conclusion:The intervention of Jianpi Huayu Decoction shows certain advantages in prolonging OS,PFS,and improving the quality of life.It is a protective factor for the prognosis of advanced colorectal cancer and has good safety. |
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