Implicit And Explicit Emotion Regulation In Breast Cancer Patients After Chemotherapy: An ERP Study

Background: It has been confirmed that cancer patients with cognitive dysfunction after chemotherapy.Female breast cancer patients are more likely to have negative emotions,and cause negative impact on the subsequent treatment and quality of life.Although there are many strategies for the regulation of emotion,the most frequently used methods by individuals are cognitive reassessment and expression inhibition.However,the neural mechanism and the results of those two emotion regulation strategies are different.The results of neural mechanisms and emotional regulation of the two strategies are all different.As the two methods of individual to regulation their emotions,explicit and implicit emotion regulation has different mechanisms,and can help individuals escape negative negative emotions effectively.Event?related potentials,as a highly specific and sensitive method,can help us understand the process of different emotional regulation strategies.After breast cancer patients completion the chemotherapy,it is not clear whether there explicit and implicit emotion regulation has changed.Objective: Trying to explore the breast cancer patients after chemotherapy implicit and explicit changes in the regulation of the school and its possible brain electrophysiological mechanisms.Methods: 20 patients with breast cancer after chemotherapy and 17 age?matched and matched patients with pre?chemotherapy breast cancer were enrolled.The implicit and explicit emotion regulation cognitive neuropsychological test paradigm was established,and behavioral tasks were investigated in patients.At the same time,the EEG activities of both groups were collected to analyze the event related potentials(ERPs)evoked by the metastatic task.The ERP differences between the two groups were compared.Results: In behavioral data,the correct rate of explicit and implicit emotion regulation in non?chemotherapy breast cancer group was higher than chemotherapy breast cancer group.In the ERP data,the N1 and P2 components in chemotherapy group breast cancer were significantly delayed.The peak values of N1 and P2 in patients in chemotherapy breast cancer group were significantly higher than those in non?chemotherapy breast cancer group.The peak value of N2 in non?chemotherapy group was significantly higher than chemotherapy breast cancer group.Conclusion: The implicit and explicit emotional regulation function of breast cancer patients after chemotherapy were worse,it may be related to the changes of N1,N2 and P2 in the ERP of breast cancer patients after chemotherapy.