Application Of The Image Fusion Technology In The Programming After Deep Brain Stimulation

ObjectiveParkingson’s Disease(PD)is a common neurodegenerative disease with cardinal signs of tremor,rigidity,Bradykinesia and abnormality of posture and gait.Deep brain stimulation(DBS)has become to the hottest therapy for PD patients because of its advantages include reversibility and adjustability.Our research is to evaluate the feasibility of the programming guided by the fused images of post-operative CT and pre-operative MRI after DBS therapy.MethodsWe used prospective study method.A total of 32 patients with PD underwent bilateral subthalamic nucleus DBS in our hospital between October 2015 and October 2017.These patients were randomly divided into two groups,including the control group and fusion group,each group has 16 cases.The control group with conventional programming was based on the physiological responses from the patients.The fusion group were reprogrammed based on the location of the contacts revealed by the fused images of post-operative CT taken at 4 weeks after surgery and pre-operative MRI.the UPDRSIII score after programing and time consuming were compared in two groups.ResultsThe average UPDRSIII score improvement rate: 49.2% of the control group and 51.1% of the fusion group,no significant differences in two groups.Timeconsuming comparison: the control group takes 3.6hours on average,and 1.9hours to fusion group,fusion group was significantly shorter than the control group.The average number of times of patients reprogramming at clinic in 6 months:9.6times per capita of the control group and 8.5 times of the fusion group.ConclusionIt is a reliable and efficient way to guide the programming by image fusion technology after DBS therapy.This method can be used in programmings of different kinds of patients who undergo DBS.