The Exploration Of Function And Mechanism Of Susceptible Gene IFN?4 Among Chinese Crohn's Disease Patients In The Animal Model

Crohn's disease(CD)is a type of inflammatory bowel disease(IBD).It is clinically characterized by abdominal pain,diarrhea,and abdominal masses as the main manifestations of chronic complex inflammatory bowel inflammation,in addition to ulcerative colitis(UC),the main clinical manifestation of pus and blood stool.Some patients have indeterminate colitis,which is characterized by clinical features and test results and cannot be clearly classified.Although UC was thought to be common in the past,as the incidence of CD in the past few decades has continued to increase,UC and CD may be equally common in North America.It genetically and environmentally interacts to manifest disease and may affect any part of the gastrointestinal system from the mouth to the area around the anus.Frequent attacks and difficult to heal,giving patients unbearable great pain.There may be many reasons to induce Crohn's disease,including infection,heredity,and genetic susceptibility.Some studies have shown that initial farm contact and early breastfeeding are also related to the development of Crohn's disease,as well as diet and smoking.In recent years,due to the development and advancement of sequencing technology,humans have used this technology to discover many candidate gene sites related to CD.In addition,the relationship between microecological variability and Crohn's disease incidence is also more and more people are paying attention to it.The above phenomenon has been clearly verified in the Crohn's patient population in the West,but it has not been found in patients with Asian diseases such as Central Plains,Japan,and South Korea.The interferon family mainly contain type ? IFN(IFN-I),type ? IFN(IFN-?)and type ? IFN(IFN-?).It is widely expressed in human organ tissues,including digestive system,respiratory system,blood and brain tissues.IFNa-4 belongs to the IFN-I family and encodes an IFNa-4 protein can both anti-inflammatory and anti-viral.It also inhibits intestinal mucosal inflammation by inducing regulatory T(Treg)cells.Because it shares the JAK-STAT signaling pathway with multiple cytokines,once it mutated,it may affect the signaling pathway,trigger inflammation,decrease the antiviral ability,and change the intestinal microecology,eventually resulting in the development of Crohn's disease.If we can find more evidence to support this speculation,we can provide reasonable prevention and treatment for vulnerable groups.