Analyse The Clinical Characteristics And Risk Factors Of Chronic Obstructive Pulmonary Disease And Lung Cancer

Objective?1?In order to analyze the clinical characteristics of patients with chronic obstructive pulmonary disease?COPD?and lung cancer,to improve the clinical understanding of COPD with lung cancer,reduce the incidence of misdiagnosis and missed diagnosis;?2?To analyze the risk factors of patients with COPD and lung cancer,and to timely prevent and screen lung cancer in COPD patients,to improve the early diagnosis rate and improve the prognosis of patients.MethodsRetrospective analysis the clinical data of Jining NO.1 People's Hospital of Respiratory Medicine in January 2015 to January 2017 admission of hospitalized patients of COPD with lung cancer in 98 cases and the same period in patients with simple COPD in 108,Statistical methods were used to statistically analyze the age,gender,smoking index,clinical symptoms,and signs,lung cancer markers,pathological types,and lung function indicators.Results?1?COPD with lung cancer patients with hemoptysis or sputum bloody,chest pain,atelectasis,hoarseness,pleural effusion,weight loss were significantly higher than patients with the simple COPD,the difference between the two groups was statistically significant?P<0.05?,There was no significant difference in the incidence of cough,sputum,and fever between the two groups?P>0.05?;?2?The male patients with COPD with lung cancer were significantly more than the simple COPD?86.7%vs 71.3%,P<0.05?,Patients with COPD were older than COPD with lung cancer?73.74±7.03 vs 66.48±1.14,P<0.01?,The smoking index of COPD with lung cancer group was significantly higher than that of the simple COPD?1426.53±380.60 vs722.22±752.98,P<0.01?;?3?The lung function classification of COPD patients with lung cancer group in the first and second grade was significantly more than the number of COPD alone?62.9%vs 54.3%,P=0.047;78.7%vs 21.3%,P<0.01?,Among them,grade II was the only;The number of lung function in patients with grade III and grade IV in the COPD group was significantly higher than that in the COPD group with lung cancer,and the difference was statistically significant?P<0.05?;Compared to COPD group,FVC?FEV₁?FEV₁/FVC?FEV₁%pred in COPD patients with lung cancer gropu were higher?P<0.05?;?4?The lung cancer markers in COPD with lung cancer group?CEA,P=0.001;CYFRA21-1,P=0.000;NSE,P=0.000?were significantly higher than those in simple COPD group,and the difference was statistically significant?P?0.001?;?5?Among 98 COPD with lung cancer,lung adenocarcinoma and lung squamous cell carcinoma in male patients were significantly higher than in female patients?P<0.05?,There was no significant difference in the patients with small cell lung cancer between male and female patients?P>0.05?;Among 98 COPD patients with lung cancer,the highest proportion of lung squamous cell carcinoma was 43.9%?43/98?,Among male patients,the most common lung squamous cell carcinoma was 48.2%?41/85?.Female patients is lung adenocarcinoma and proportion Up to 53.8%?7/13?;?6?Binary logisticregression analysis showed that:male[OR=19.946;95%CI=6.531,6.914],age?65years[OR=2.143;95%CI=1.348,3.405],smoking index?400 branch/year[OR=3.827;95%CI=1.822,8.040],GOLD?[OR=10.795;95%CI=3.526,33.044]and GOLD?[OR=22.252;95%CI=5.431,11.173]are risk factors for lung cancer in COPD patients.Conclusion?1?The result show that when patients with a history of COPD have hemoptysis or sputum bloody,chest pain,atelectasis,hoarseness,pleural effusion,weight loss of clinical manifestations and signs and lung cancer markers are rising,should pay attention to the possibility of lung cancer.?2?Male,age?65 years,smoking index?400 branch/year,GOLD II,and GOLD III grade are risk factors for lung cancer in COPD patients.Lung cancer screening for these patients should be promptly conducted.