Clinical Study On Treatment Of Qi Depression And Phlegm Obstruction In Non-erosive Reflux Disease With Xing Qi Hua Tan Soup

1 Objective Understand the clinical efficacy and the effect on life quality of the program through observing the effect of Xing Qi Hua Tan soup on gastroesophageal reflux disease questionnaire(Gerd Q)integral,TCM syndrome integral and the MOS item short form health survey(SF-36)scale of non-erosive reflux disease(NERD)patients before and after treatment.2 Method Sixty patients with NERD are randomly divided into treatment group(n = 30)and control group(n = 30).The patients in treatment group are treated with Xing Qi Hua Tan soup,and those in control group are treated with rabeprazole enteric-coated tablets.The total course of treatment is 8 weeks.The changes of Gerd Q integral,SF-36 scale and safety index before and after treatment are observed.Then stop the medicine to follow up after 3 months to judge the curative effect of the Xing Qi Hua Tan soup.3 Results3.1 Gerd Q integral After two groups of treatment,the total score of Gerd Q integral is significantly lower than that before the treatment(P<0.01).The clinical effect of the treatment group is better than that of the control group(P<0.05).The total effective rate of Gerd Q score in treatment group is 93.1% and that of Gerd Q score in control group is71.4%.In terms of single integrals,the clinical efficacy of reflux,heartburn and sleep disorder in the treatment group is better than that in the control group(P < 0.05);the improvement of nausea symptoms in the treatment group is better than that in the control group(P < 0.05);both groups can improve the use of additional drugs(P <0.05),but there was no difference between the two groups(P > 0.05);neither of the two groups has an ideal effect on improving symptoms of abdominal pain(P > 0.05).3.2 TCM syndrome score After treatment,the total effective rate of TCM syndrome in the treatment group and the control group is 93.1% and 67.86% respectively,and the treatment group is obviously superior to the control group(P<0.05).After treatment,the TCM syndrome of the treatment group has a statistic difference compared with that before the treatment(P < 0.01 or P < 0.05);the symptoms of the control group is lower than that before the treatment(P < 0.01 or P < 0.05);after treatment,throat discomfort score is significantly lower than the control group(P < 0.01)with chest pain,belching or regurgitation,dysphagia symptom score lower than the control group(P<0.05);after treatment,the symptom scores in the control group are higher than the treatment group.Th hoarseness and coughing at midnight of the two groups are lower than those before the treatment,but there is no significant difference between the two groups(P > 0.05).3.3 SF-36 scale integration After treatment,physiological function score of the two groups has no significant difference compared with that before the treatment(P>0.05);of social function and integral activity of the two groups are higher than those before the treatment(P < 0.01 or P < 0.05),but there is no significant difference between the two groups(P > 0.05);after treatment,the physiological function,emotional function and mental health,body pain,general health scores of the two groups are higher than those before treatment(P < 0.01 or P < 0.05),and the treatment group is higher than the control group(P < 0.01 or P < 0.05).3.4 Comparison of recurrence Patients stop the medicine followed up after three months.The recurrence rates in the treatment group and control group are 10.34% and 32.14% respectively.The treatment group is better than that in control group in terms of decreasing the recurrence rate(P < 0.05).3.5 Safety of drug use There is no significant difference in safety index monitoring between the two groups during the treatment period.There is no adverse reaction time after the end of treatment,so the safety of the two groups is good during the study period.4 Conclusions4.1 Xing Qi Hua Tan soup can obviously improve the clinical symptoms of acid reflux,and the overall improvement of Gerd Q and the total effective rate of clinical symptoms are better than those of the control group.The treatment group has the exact curative effect on the reflux,heartburn,and sleep disorder symptoms;for nausea symptoms,the curative effect of the treatment group is better while that of the control group is not good;both groups can improve the patient's use of additional drugs,but the efficacy of the two groups has no difference;the upper abdominal pain symptom improvement of the two groups is not ideal.4.2 Xing Qi Hua Tan soup can improve the TCM syndrome score of resistance type NERD significantly and the overall effect is better than that of the control group.The treatment group can improve patients' symptoms of throat discomfort compared with the control group;for retrosternal discomfort,belching or regurgitation,dysphagia,the treatment group is better than the control group;the two groups can alleviate the symptom of cough and hoarseness at midnight,but the curative effect between the two groups has no significant difference.4.3 Both the treatment group and the control group can improve the life quality of the patients with NERD,and the treatment group is more reliable to improve the life quality of the patients.4.4 The recurrence rate of the treatment group is lower than that of the control group,and the difference has statistical significance.4.5 The safety of Xing Qi Hua Tan soup is more reliable.