Correlation Of Ki-67 And TIA-1 To Radiotherapy Sensitivity Of NK/T Cell Lymphoma

NK/T cell lymphoma(NKTL)is a type of non-Hodgkin lymphoma classification.It is derived from NK cells or T cells and is therefore called NK/T cell lymphoma.NKTL occurs in different parts,the tumor site mainly accumulates nasal cavity,nasopharynx,upper palate,tonsil,lower pharynx,larynx and other external organs,other parts are not common,therefore,it is also called extra-nodal NK/T cell lymphoma(nasal type).NKTL is a highly invasive lymphoma with poor prognosis.At present,most NKTL expressed multidrug resistance gene mRNA and the expression product of multidrug resistance gene P-glycoprotein(PgP),which resulted in multidrug resistance in cells.Therefore,the effect of chemotherapy on NKTL is poor.Early diagnosis of NKTL treatment is mainly radiotherapy,late use radiotherapy combined with chemotherapy treatment.Radiotherapy is the main treatment for stage I and II patients.However,the sensitivity of different patients to radiotherapy is different.This paper intends to study the correlation between the expression of Ki-67 and TIA-1 and the sensitivity of radiotherapy in order to judge the short-term efficacy of radiotherapy.Objective:To investigate the correlation between the expression of Ki-67 and TIA-1 and the radiosensitivity of NK/T cell lymphoma,hope to speculate that there is a statistical significance in predicting the radiosensitivity of NK/T cell lymphoma.Materials and methods:From March 2014 to September 2017,80 patients diagnosed in the first affiliated Hospital of Zhengzhou University and received radiotherapy in our hospital were selected.They were divided into two groups,namely,radiotherapy sensitive group and radiotherapy resistance group.Radiotherapy sensitive group were the patients with complete remission after radiotherapy(CR),radiotherapy resistance group was a patient with no complete remission after radiotherapy(PR?PD?SD).The expression of Ki-67 and TIA-1 in patients before radiotherapy was detected by immunohistochemical method.Data processing using Statistical Software IBM SPSS Statistics 22.0,the data were processed by?~2 test,Fisher accurate probability test and correlation analysis.Results:1)The positive expression rate of ki-67 in NK/T cell lymphoma was 77.50%,and the positive rate of TIA-1 in NK/T cell lymphoma was 76.25%.2)There was no correlation between the expression of ki-67 and TIA-1 in NK/T cell lymphoma(P>0.05).3)The positive expression rate of ki-67 was related to the stage of NK/T cell lymphoma(P<0.05);TIA-1 was not related to the clinical stage of NK/T cell lymphoma(P>0.05).4)The expression of ki-67 and TIA-1 was not correlated with sex and age(P>0.05).5)The expression of ki-67 and TIA-1 were correlated with the radiosensitivity of NK/T cell lymphoma(P<0.05).Conclusion1)The positive rates of TIA-1 and ki-67 were higher in NK/T lymphoma patients.The positive rate of TIA-1 and ki-67 expression was not related to age and sex.2)The expression of ki-67 was related to the stage of NK/T lymphoma,and the higher the stage was,the higher the expression of ki-67 was.The expression of TIA-1was not related to the stage of NK/T lymphoma.3)The expression of Ki-67 and TIA-1 in NK/T lymphoma is related to the radiation sensitivity of the disease.Therefore,it is inferred that Ki-67 and TIA-1 can be used as an indicator of short-term efficacy of radiation therapy.