Study On The Relationship Between G-protein Coupled Receptors And Psoriatic Skin

Psoriasis is recognized as a common,chronic inflammatory disease of the skin with a considerable impact on quality of life because of pruritus and cosmetic considerations.Psoriasis is a disease that can occur in one of several forms,the most common being plaque psoriasis,which presents as well demarcated plaques of erythematous skin covered with white,flaky scales.Defining histological features of psoriatic skin lesions include epidermal hyperplasia(acanthosis),caused by a aberrant terminal differentiation and hyperproliferation of epidermal keratinocytes,as well as marked infiltration of mononuclear leukocytes into the dermis.Despite a number of effective treatments,new therapies are needed with enhanced efficacy,safety,and convenience.GPCR(G-protein coupled receptor)superfamily is the largest family of cell-surface molecules associated with signal transduction.Chemokine receptors are G protein-coupled receptors that control leukocyte trafficking,and like other G protein-coupled receptors,are effective potential drug targets.Although the expression of a number of chemokines and the chemokine receptors are increased in inflammatory psoriatic skin as compared to non-lesional skin,whether G-protein coupled receptors play a sufficient role in the pathogenosis of psoriasis is still unknow.Microarray expression profiling andRT-PCR were used to characterize gene expressions that relate to G-protein coupled receptors with >2-fold changes in psoriatic lesions and non-lesion skin from three plaque psoriasis patients.RT-PCR detection was used to verify the differentially expressed genes tested by microarray assay.Our purpose is to indicate the possible role for G-protein coupled receptors in disease machanism at the genetic level and discuss the possibility of inhibiting G-protein coupled receptors as treatement for individules of psoriasis in the future.