TFF2 Regulates Lps-induced Macrophages Polarization And Inhibits Inflammation

The polarization of macrophages plays an important role in the repair of pathogen infection.On the one hand,macrophage M1 initiates the inflammatory mechanism,activates and releases the inflammatory mediators,causing the inflammation to occur and thus result in damage.On the other hand,macrophage M2 induces the anti-inflammatory mechanisms,mainly involved in inflammation and parasitic infection resistance control,and plays a role in tumor formation.Different types of macrophages interact with the microenvironment to initiate proinflammatory or anti-inflammatory mechanisms that determine the development and progression of inflammation.Therefore,Macrophage is not only an important target for disease treatment,but its polarization is also one of the hot topics in the research filed.The latest researches in macrophage polarization suggest that lipopolysaccharide(LPS)is a powerful inducer of inflammation and macrophage M1 polarization,which plays a key role in the mechanism of Helicobacter pylori infection gastritis injury.Otherwise,a large number of studies have shown that soluble small molecule peptides secreted by gastrointestinal mucus cells have multiple biological functions in mucosal injury repair,inflammatory protection and tumor development,which are reported as potential novel tumor markers.As a member of TFFs,Trefoil factor 2(TFF2)is also closely related to the pathological changes of gastric mucosa after Helicobacter pylori infection.This study involes in the function and mechanism of the regulation in LPS-induced macrophages polarization and inflammation by TFF2.This study intends to explore:1)the expression induction pattern of TFF2 by LPS;2)the inhibitory effect and molecular mechanism of TFF2 on macrophage M1 polarization;3)TFF2 inhibits inflammation induced by LPS antagonists;4)the inhibition effects of TFF2 on macrophage polarization and inflammatory after H.pylori infection.After reasonable design and a large number of experiments,this study puts forward the TFF2 upregulation of macrophage polarization stress inhibits LPS induced macrophages polarization and inflammation.Thus,this paper will establish TFF2 as a macrophage polarization control factor and a gastric mucosal inflammation therapeutic target.