Effect Of Depression On Reproductive System Of Female Mice

Depression,a human disease,is found in the earlier period,but is gradually emphasized in recent years.It could be argued that it becomes a "rising star" of human disease.However,depression is similar to other mental and psychological diseases,its pathogenesis is not clear up to now.By scientists' study,a great number of hyphothesis about pathogenic factors and pathogenesis are pointed,and much medicines based on different mechanisms is discovered,which contributes much to the disease of people's cognition and remedy.Meanwhile,due to its high morbidity,unclear pathogenic factors,complicated pathogenesis,and difficult cure,depression still perplexes every observer and researcher,let alone sufferers.We also find that depression's morbidity has shocking variation on sex,suffering rate of women is far more than men,which has deep relation with social structure's change.Women not only shoulders great mandate of gestating next generation,but also the responsibility of heavier life pressure under the circumstance of heavier life pressure,which require women to finish "internal and external consideration".The influence of depression on organism is wide and profound,not only bringing to brain's structural changes,but also functional impairment of body,which maybe has an influence on woman's reproductive function.In order to study the influence of depression on reproductive system,aiming at female,the study checks its inside changes of reproductive system by making depression's disease model.Adopting chronic unpredictable mild stress method and with the test of behavior,modeling checks reproductive system of depression mice on many aspects,such as morphology,apoptosis,histone modification and offspring mice.The result reflects that depression has large influence on reproductive system of female mice and the reproductive ability of female mice remarkably weakens.