The Relationship Between The Plasma Homocysteine Levelswith Coronary Artery Disease

[Background]Recentepidemiological studies suggested that the plasma homocysteine level was an independent risk factor for coronary artery disease(CHD),whereas it remains controversial.[Objective]The aim of this study was to explore the correlation between the plasma homocysteine levels and CHD in further,and to imply the clinical significance of monitoring and adjusting the levels of plasma homocysteine levels in the risk population.[Methods]One hundred ninty two patients with suspected CHD were enrolled continuously to the study who visted to the Cardiology Department of the First People's Hospital of Hangzhou between January 2015 and April 2015.According to the results of coronary angiography,the patients were invided to CHD group and non-CHD group.CHD group included the patients with 1,2 or 3 vascular lesions and AMI.The results of imaging showed that 1 or more than 1 coronary stenosis more than 50%(diameter)were belong to the patients with 1,2 or 3 vascular lesions,respectively.The automatic biochemistry analyzer was used to determine the fasting plasma levels of Hcy,high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC),creatinine(CR)and the levels of CR clearance(eGFR).[Results]The results of coronary angiography showed 142 cases of CHD group and 50 cases of non-CHD group.There were no significant difference in CHD group and non-CHD group with respected to the presence of hypertension,diabetes,alcohol consumption,the levels of plasma TG and LDL-C(P>0.05),while the obviously differences were founded in the gender,age,smoking,the levels of plasma Hcy,HDL-C,CR and eGFR,respectively(P<0.05).CHD group had a significantly higher plasma Hcy levels than non-CHD group(P<0.05).Of those,the patients with 2,3 vascular lesions and AMI were obviously higher plasma Hcy levels than non-CHD group(P<0.05).Moreover,the plasma Hcy levels of CHD patients were positively correlated with the numbers of coronary artery lesions(r =0.310,P<0.01).[Conclusion]1.High plasma Hcy level was one of CHD risk factors;2.The plasma Hcy level was correlated with the severity of coronary artery lesions.