The Efficacy Study Of Short-term Intensive Statin Therapy In Patients With Acute Coronary Syndrome

[Objective]To investigate the clinical efficacy and safety analysis of short-term intensive statin therapy in patients with acute coronary syndrome.[Methods]A total of 218 ACS patients who were treated in Hangzhou First People's Hospital from March 2013 to July 2013 were enrolled into this study.They were randomly divided into the intensive group and conventional group according to odd and even numbers.The intensive group patients were given 80mg atorvastatin on hospitalization.,and after discharged get atorvastatin 40mg/night for one month;The general group patients were given 20mg from they came to our hospital.,and after discharged get atorvastatin 20mg/night for one month.All the patients were given the biochemical indexes detection both on the first day and after one months treatment The results using SPSS 17.0 software for processing,measurement data with x ± s,said groups of data were compared using a t test was used to compare the data within the group paired t test,count data were expressed as a percentage,using the ?2 test.[Results]Comparison of baseline indicators,in addition to the two groups of patients smoking history,gender,age,heart rate,body mass index(BMI),underlying diseases(hypertension,history of diabetes),previous history and taking statin medications after admission basis(statins,aspirin,angiotensin converting enzyme inhibitors(ACEI),angiotensin receptor blockers(ARB),?-blockers,calcium antagonists,clopidogrel,nitrates),and no significant differences.Comparison of monitoring indicators,in addition to strengthening the group of patients with HCY higher than the conventional group,the room showed no statistically significant difference in the rest.There is no significant difference in the diagnosis of type on the difference between the two groups of patients(unstable angina(UA)ST-segment elevation myocardial infarction(STEMI)and non-ST segment elevation myocardial infarction(NSTEMI)).In addition,on undergoing coronary angiography alone or the stent implantation,there is no statistically significant difference in two groups of patients.After one month's treatment,thetriglycerides?total cholesterol and LDL cholesterol of intensive group were significantly lower than baseline(respectively 1.52±0.88 vs.0.75±0.14 m mol/L,P<0.05;4.55±1.12 vs.2.21±0.78 m mol/L,P<0.05;2.23±0.77 vs.1.76±0.31 m mol/L,P<0.05),and the high density lipoprotein cholesterol was higher(1.15±0.34 vs.1.52±0.41 m mol/L,P<0.05);compared with the conventional group,the intensive groups liver enzymes creatine kinase was no significant increase,but the creatinine levels decreased than before(82.53±23.85 57.81±15.27 u mol/L,P<0.05),there is a certain protective effect of renal function,and the patient's blood homocysteine and ultra-sensitivity C-reactive protein levels decreased compared with the previous(30.70±18.82 vs.10.52±4.66 m mol/L,P<0.05;19.75±11.91 8.06±2.68 mg/L,P<0.05).[Conclusions]Short-term intensive statin therapy can quickly and effectively reduce blood lipid,cholesterol levels and homocysteine levels,raise HDL cholesterol,and have some anti-inflammatory,renal protective effect under the premise of drug safety,and provide more clinical benefit in patients with ACS.