Different Dose Intensity Of Anthracycline By Two-dimensional Speckle Tracking Imaging

Objective To assess the early value of two-dimensional speckle tracking imaging(STI)in detecting cardiac function of breast cancer patients treated with different dose of anthracycline.Methods Eighty cases of female breast cancer patients were selected and they were given 6-cycles Epirubicin-based chemotherapy.The left ventricular mean longitudinal,radial,circumferential systolic strain rate(SRs),early diastolic strain rate(SRe)and later diastolic strain rate(SRa)in the basal,middle and apical levels were assessed before one day and after the third day of every chemotherapy,as well as the conventional echocardiography,and all the parameters were analyzed by own control.Results The conventional echocardiographic parameters:at A5(the fifth chemotherapy)?A6(the sixth chemotherapy),the cumulative dose at 450 mg/m2?540 mg/m,E/A?Em/Am was significantly reduced,when compared with AO(before given chemotherapy)(P<0.05).The parameters of STI:At A3(the third chemotherapy),the cumulative dose at 270mg/m2,the SRe?SRa started to deduced(P<0.05)and all deduced significantly at A5?A6(P<0.01);the SRs deduced at A5 and A6(P<0.05).Conclusions With the proceeding of chemotherapy,the parameters of SRI change earlier than that of conventional parameters.Therefore the damage of cardiac function caused by anthracycline can be detected by STI earlier in breast cancer patients.