The Role And Molecular Mechanism Of REG-? In Thyroid Tumor Development

REG? protein belongs to the 11S proteasome activator,it can activate proteinsome,to de,grade some target proteins,including p21,p16,SRC-:3,and so on.RFG? also plays a crucial role in tumorigenesis and development,The abnormally high expression of REG?is found in a large scale of tumor tisues.There.i s also high expression of REG? in thyroid tumors,especially in poorly-di fferentiated thyroid carcinoma.This paper was aimed to study the role of REG? in thyroid tumors.We study the role of REG? by focusing on its effect on thyroid carcinoma differentiat ion state,the migration abili ty of thyroid tumor cells,cell proliferal ion and cell apoptosis,and we explore the molecular mechanism.Conclusions were drawed that:REG? inhibited the expression of thyroid-specific genes,REG?promoted the migration ability of thyroid tumor cells,cell proli feration was promoted by REG?,REG?rendered cel Is anti-apoptosis effect,REG? helped PKA?translocated into nuclear much easier,REG? decreased the protein stability of PKA a and it inhibited t he expression of PKA?.The regulation of thyroid-specific gene expression by REG? was mediated by the cAMP-PKA signal pathway.Besidos,both REG?and MAPK signal pathway were involved in the regulation of thyroid-specific gene expression.It seemed REG? played a crucial role in tumorigenesis and development,so studying on role and mechanism of REG? had critical clinical significance.REG?inhibited the expression of thyroid-specific genes,including NIS gene,which made the clinical treatment with radioactive I131 have litile effect.REG? rendered cells anti-apoptosis ability,which also made the treatment difficult.We can regard REG? as a target protein in future study and clinical treatment by decreasing its expression or lowering its activi ty,which would have positive meaning in thyroid tumor treatment.