Advance In Molecular Targeted Therapy For HER-2 Positive Breast Cancer

Objective: To explore advance that related with molecular targeted therapy for HER-2 positive breast cancer.Methods: Through summarizing and analyzing the latest domestic and foreign literature on molecular targeted therapy for HER-2 positive breast cancer,I will make a review comprehensively.Results: Around the world,breast cancer is the most common malignant tumor of the women,which forms great threat to female's life and health.The patients having the same clinical stages and histological types who treated with the same method have the different sensitivity and prognosis at last.This suggests that traditional indicators of the clinical prognosis such as clinical stage,postoperative pathologic stage and pathology classification can't reflect the biological characteristics of breast cancer exactly and confirms that breast cancer is a kind of highly heterogeneous disease on molecular level.Following by the improvement of laboratory technology and the rapid development of molecular biology,through the further research on the pathogenesis,treatment and prognosis at the molecular level,now we have a lot of discovery and achievement.The research on the HER-2 gene and the relevant research on genetic typing,operation,chemotherapy,molecular targeted therapy and endocrine therapy all have great breakthrough.Now through the summary of the latest domestic and foreign literature,we find the important guiding value of the HER-2 gene in the diagnosis,treatment,and prognosis evaluation of breast cancer.For the HER-2 positive breast cancer,we should attach great importance to them and adopt individualized therapy.Conclusion: Breast cancer is a highly heterogeneous disease and the HER-2 gene plays an important role in diagnosis,treatment and risk assessment.Before and after the operation,breast cancer patients must be carried on detailed genotyping,especially focusing on the expression of the HER-2,and make further evaluation about the degree of malignant tumor and the long-term risk of recurrence and metastasis.For HER-2 positive breast cancer,we must choice individualized surgical procedure and adjuvant therapy,so as to enhance the cure rate,reduce the risk of recurrence and metastasis,improve the life quality and prolong the survival.