Amide Proton Transfer Magnetic Resonance Imaging In Patients With Intracerebral Hemorrhage

Objective:To explore the value of amide proton transfer(APT)Magnetic Resonance Imaging(MRI)in detecting intracerebral hemorrhage(ICH).Methods:28 patients with ICH underwent routine MRI,SWI and APT imaging scanning at 3.0 T(Magnetom Trio Tim,Siemens AG,Erlangen,Germany)using a 12 channel head coil.The MRI findings were evaluated,the values of SWI and APT-weighted(APTw)MRI in the hemorrhage lesions were measured and compared with the contralateral normal brain tissues at different stages.Wilcoxon matched-pairs signed ranks sum test,Mann-Whitney U test and receiver operating characteristic curve(ROC)were used for statistical evaluation.Results:All the ICH lesions were hyperintense on the APTw MRI.However,SWI showed hypointense in 15 cases and mixed signal intensity in the other 13 cases.The values of APTw signal intensities were higher in the hemorrhage lesions than those in the contralateral normal brain tissues(P<0.05)at different stages.And the SWI signal intensities were lower in the hemorrhage lesions(P<0.05)except that at subacute stage(P>0.05).From hemorrhage tissue,the values of APTw signal intensities had grater areas under ROC curve than that of SWI(P<0.05).Conclusion:APT MRI is sensitive in detecting ICH,which may provide a new noninvasive MRI tool for early detecting ICH.