Studys On The Preparation And Quality Standards Of Yuye Decoction Agent

Yuyetang comes from Intergrating Chinese and Western Medicine by Zhang Xichun,Composed of Chinese yam,astragalus,Radix trichosanthis,Rhizoma Anemarrhenae,Ge Gen,Kanekin,Schisandra seven herbs.Has the efficacy of Yiqi,solid kidney thirst.Treating diabetes disease,symptoms of thirst to drink,drink sleepy puzzled,shortness of breath,frequent urination quantity,or cloudy urine etc..Clinical commonly used to the treatment of diabetes,cancer radiotherapy,infantile summer fever,hyperthyroidism,diabetes insipidus,saw thirst urine belongs to the asthenia of both the spleen and kidney.This topic by the theory of traditional Chinese medicine as a guide,and systematically reviewed the a large number of relevant documents,and combining with the drug's clinical effect,as well as the traditional Chinese medicine technology requirements of the decoction were dosage form reform,fried paste was developed,and the decocted ointment preparation process,quality standards and the preparation of the stability studies.Preparation:in traditional decoction of preparation technology as a basis,according to the characteristics of the prescription of every flavor medicinal chemical constituents,biological activity,pharmacological action and clinical application,develop reasonable extraction process route.And through the single factor experiment,water absorption of medicine were investigated,to determine the best soaking time;through L9(34)orthogonal test,to water,extraction times and time of extraction were investigated,to determine the optimum extraction conditions;through enrichment experiments,concentrated on pressure,temperature and relative density were investigated,to determine the appropriate conditions of concentration and scope;molding process,according to the kinds and amount of the excipients were investigated,preferably a suitable excipients;and forming process of the preparation and test system are studied,to establish a scientific and reasonable process route for the preparation of.Quality Standards:to ensure the preparation is stable and controllable in quality.This topic using modern pharmaceutical technology,quality standards of Yuye Decoction paste were studied.Using thin layer chromatography(TLC)of two kinds of Chinese medicine preparation of Radix Astragali,Radix Puerariae were identified by TLC;high-performance liquid phase chromatography for preparation of monarch drug Radix Astragali effective components of astragaloside IV was determined,and the method test research,established the Yuye Decoction paste quality standard system.Preparation of preliminary stability test:by leaving sample observation of the preparations for the period 6 months of stability investigation,respectively in 0 months,1 month,2 months,3 months,6 months regularly on the preparation of traits,identification,inspection and determination project were detected.The results showed that all the indexes had no significant difference,are in line with the "Chinese Pharmacopoeia" version of the 2015 a relevant Jiangao agent under the provisions.