Research Of The Curative Effect Of Potassium Channel Openers In Coronary Artery Slow Flow Phenomenon

Objective:By observing the patients with coronary slow flow phenomenon after taking potassium channel openers agent-nicorandil,observe the subsequent clinical manifestations,electrocardiogram ST-T change,serum CRP and Myocardial Contrast Echocardiography K value index,to evaluate nicorandil's,curative effect of coronary artery slow flow phenomenon.Methods:Gather 60 patients in shanxi da yi hospital and was admitted because of chest tightness,chest pain,confirmed as coronary slow flow Phenomenonby by coronary angiography,all patients were divided into 2 groups,control the basic diseases and other risk factors at the same time,the control group were given oral aspirin 100 mg once a day,and atorvastatin calcium table 20 mg once a day.In the treatment group,nicorandil tables were added,5mg/ dose,3 times a day,and the course of treatment was 3 months.before the study begin,all patients were signed the informed consents.At the end of treatment,the changes of each index of the two groups were observed.Myocardial Contrast Echocardiography was used a special acoustic micro bubbles as contrast agents for myocardial perfusion imaging,is a new kind of detection way to inspection the myocardial microcirculation integrity and myocardial perfusion in recent years.In this study,both the two groups of patients were all underwent the myocardial contrast echocardiography before and after the treatment.Results:1.Comparison the two groups of patients after the treatment,the symptoms of chest pain,and changes in electrocardiogram ST-T were observed,and the total effective rate of the treatment group was higher than that of the control group(P<0.05).2.In the comparison between the two groups of patients,the frequency and duration of chest pain onset after treatment were both improved compared with those before treatment(P<0.05),and the effect of the treatment group was better than the control group(P<0.05).3.The two groups of patients with blood biochemical indexes: blood glucose,total cholesterol,triglyceride,low density lipoprotein cholesterol(hdl-c),allergic C-reactive protein after treatment were all decreased(P<0.05),comparison between the two groups only allergic C-reactive protein changes have statistical difference(P<0.05).4.After treatment,he two groups with left ventricular end-diastolic diameter(LVIDd),end systolic diameter(LVIDs),ejection fraction(EF)have no significant change(P>0.05),but two groups after treatment in patients with cardiac diastolic function of E/A value is compared with the previous increased(P<0.05)and effect of the treatment group was better than control group(P<0.05).5.As for myocardial contrast echocardiography,after treatment,the two groups with local myocardial blood flow velocity of the K value,were all improved(P<0.05).the comparison between the treatment group and the control group,whicn has the statistically significant difference(P<0.05).Conclusion:1.Aspirin antiplatelet aggregation and anti-inflammatory statin therapy based on the combination of nicorandil with coronary slow blood flow can improving coronary blood flow in patients with chest pain onset symptoms,duration,frequency,reduce the onset of chest pain and improve the ecg ST-Tchange and ascension slow blood flow in patients with myocardial ischemia area blood perfusion rate,better than aspirin alone with atorvastatin therapy.2.Myocardial Contrast Echocardiographyimaging examination can be objective evaluation from the perspective of noninvasive imaging myocardial perfusion in patients with coronary slow flow,the possibility of the evaluation of curative effect after treatment in patients with coronary slow flow provide new inspection methods.