Correlation Between Smoking And Coronary Atherosclerosis

Objective: Smoking is an independent risk factor for coronary heart disease,this study is intended to explore the relationship between smoking index and the degree of coronary atherosclerosis.Methods: This case study retrospectively enrolled 127 male patients with coronary heart disease confirmed by coronary angiography.(1)According to whether smoking was divided into smoking group and non-smoking group,the general data(age,height,weight,BMI,prevalence of hypertension,prevalence of diabetes)and laboratory parameters(alanine aminotransferase,aspartate aminotransferase,fasting blood glucose,urea nitrogen,serum creatinine,total cholesterol,triglycerides,high density lipoprotein,low density lipoprotein)(2)Smoking groups were divided into three groups according to SI: mild(0-400),moderate(401-800),severe(> 800),and general patient data(age,height,weight,BMI,prevalence of hypertension,prevalence of diabetes)and laboratory parameters(number of leukocytes,neutrophils,lymphocytes,monocytes,erythrocyte count,hemoglobin,platelet count,alanine aminotransferase,aspartate aminotransferase,fasting blood glucose,urea nitrogen,Serum creatinine,total cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein).The Gensini score was compared with the coronary angiography to compare the Gensini score among the three groups.(3)Spearman rank correlation analysis of SI and age,Gensini score.Results:(1)The Gensini score of smoking group was higher than that of non-smoking group,the difference was statistically significant(P = 0.028).(2)According to SI group,the average age of the mild,moderate and severe groups were(52.36 ± 10.82),(58.30 ± 7.73)and(59.64 ± 10.30),respectively,with statistical significance(P = 0.011)(21.04 ± 13.60),(30.30 ± 29.83),(41.00 ± 37.67),respectively.The difference was statistically significant(P = 0.040).There was no significant difference between the other three groups.(3)Spearman correlation analysis showed that SI was related to the mean age and Gensini score(r = 0.298,P = 0.002;r = 0.264,P = 0.008)Conclusion: Smoking is an important risk factor for coronary artery stenosis.For patients with coronary heart disease,the degree of coronary stenosis is positively correlated with the smoking index.To some certain extent,the smoking index can reflect the severity of coronary atherosclerosis.