Study On The Relationship Between Sperm Morphology And The Pregnancy Outcome Of In Vitro Fertilization Embryo Transfer

Objective:To study the predictive value and effects of the sperm morphological parameters on the pregnancy outcome of normal in vitro fertilization embryo transfer(IVF-ET)before ovulation induction.Methods:502 pairs of couples who received routine IVF-ET assisted pregnancy were selected and divided into into three groups according to normal sperm morphology rate in the 3 months before ovulation induction: Group A: NSMR< 4%,Group B: 4%?NSMR<15% and Group C: NSMR ?15%;and then compare the functional parameters of different groups of sperm and their fertilization rates,normal fertilization rates,cleavage rates,good-quality embryo rates,implantation rates and pregnancy rates during the IVF-ET process.Result:1.No differences in semen volumes between the three groups(P>0.05),but significant differences in sperm density and vitality(P<0.01);2.No apparent differences in fertilization rates,normal fertilization rates,cleavage rates,good-quality embryo rates and implantation rates(P>0.05),only the fertilization rates of Group A are slightly lower than those of other two groups,whereas the normal fertilization rates of Group C are slightly higher than those of other two groups;3.No significant differences in biological and clinical pregnancy rates,ectopic pregnancy rates,early and late abortion rates,and live birth rates(P>0.05).However,the rate of early abortion decreased with the increase of NSMR.Conclusion:The morphology of sperm is closely related with its functions,with the increase of the normal sperm morphology rate,the semen density and vitality increased significantly.Prediction of the pregnancy outcome of IVF-ET merely by sperm morphology is not entirely reliable.