Study On The Correlation Between Insulin Resistance And TCM Syndromes Of PCOS With Abnormal Insulin Release Curve

Objective:To collect polycystic ovary syndrome with the abnormal insulin release curve,analysis the correlation of endocrine and metabolic indicators and TCM syndromes between different levels of HOMA-IR and BMI,so as to guide clinical.Methods:Collected 204 patients with PCOS and abnormal insulin release curve.By using the case table,we register the general condition,anthropometric indicators,menstrual conditions,symptoms,tongue,pulse,OGTT,insulin release test,sex hormones and B ultrasonography of the patients.Syndrome is divided into Kidney Deficiency and Blood Stasis,Spleen Deficiency and Phlegm Dampness,Kidney Deficiency and Liver Qi Stagnation,Phlegm and Blood Stasis.According to HOMA-IR,the patients were divided into four groups as the IR1 group,R2 group,IR3 group and IR4 group.According to BMI the patients were divided into normal weight group,overweight group,obese group.Analyzed the correlation of endocrine and metabolic indexes and TCM syndromes between different HOMA-IR and BMI.Results:1.In the 204 patients,21-27 years old was 93 cases(45.6%),28-34 years old was 70 cases(34.3%),21-34 years old was the main age of onset of this study population.2.Different HOMA-IR and BMI patients in the course of disease and anthropometric indicators were statistically significant(P <0.05).3.There were significant differences in fasting blood glucose and OGTT 2 hours blood glucose in different HOMA-IR patients(P <0.05).Blood glucose was not statistically different at different time points in different BMI patients.4.There were statistically significant differences in insulin levels between different HOMA-IR and BMI groups(P <0.05).Insulin levels were positively correlated with HOMA-IR and BMI.5.There was a significant correlation between LH,LH / FSH and T in different HOMA-IR and BMI.HOMA-IR and BMI were negatively correlated with LH,LH /FSH,and positively correlated with T(P <0.05).6.There were significant differences in the distribution of TCM syndromes in different HOMA-IR and BMI patients.Spleen deficiency phlegm-dampness syndrome and phlegm-blood stasis syndrome were the main syndromes in IR3 group,IR4 group and obesity group.7.LH,LH / FSH,T,PRL were statistically different in different syndromes(P<0.05).Conclusion: 1.The HOMA-IR could in the normal range in the PCOS patients with abnormal insulin release curve.The main syndromes were kidney deficiency blood stasis syndrome and kidney deficiency liver qi stagnation syndrome.In the PCOS patients with abnormality of insulin release,with the increase of HOMA-IR and BMI,Spleen Deficiency Phlegm Dampness Syndrome and Phlegm and Blood Stasis Syndrome gradually become the main syndromes of PCOS,the longer the course PCOS is more likely to show phlegm and blood stasis.2.Insulin resistance in patients with severe PCOS more prone to glucose metabolism disorders and hyperandrogenism.Kidney deficiency and blood stasis than other syndromes have a higher level of LH,kidney deficiency syndrome than other syndromes have a higher PRL level.