Analysis Of The Risk Factors Of Deep Venous Thromboembolism With Epithelial Ovarian Cancer

Objective:Venous thromboembolism(VTE)is one of the common complications of the epithelial ovarian cancer(EOC),and the incidence of endometriosis has shown an upward trend year by year.VTE can be divided into Deep venous thrombosis(DVT)and Pulmonary embolism(PE),usually we most talk about DVT.DVT not only has a poor prognosis,reduce the suirvival time,but also has bad influence on the treatment.So,we should pay more attention to the DVT when we take care of the EOC patients.The causes of DVT are various.In this research,we will identify the risk factors for DVT in ovarian cancer patients,to provide a reference for the prevention of DVT.Methods:80 cases of epithelial ovarian cancer patients were collected from Affiliated Hospital of Qingdao University between Jan.2010 and Jan.2016,including 20 cases of epithelial ovarian cancer with DVT group,60 cases in the epithelial ovarian cancer without DVT group(according to 1?3 proportion by the computer random method to selecting patients without DVT as the control group).In the same way,select 60 cases in the benign ovarian tumor group.FIGO stage and grade of cancer,blood coagulation and survival data were analyzed.Results:1.Among 60 cases of EOC without DVT,39 patients are diagnosed with ovarian serous adenocarcinoma,9 patients are diagnosed with mucinous adenocarcinoma,7 patients are diagnosed with clear cell caicinoma,5 patients are diagnosed with endometrial adenocarcinoma.The histological grade is 38 patients can be grouped into G3,while 22 patients are grouped intoG1+G2.Accroding to FIGO stages,there are 24 patients in the group of I~II,and 36 patients in the group of III~IV.Among 20 cases of EOC with DVT,11 patients are diagnosed with ovarian serous adenocarcinoma,5 patients are diagnosed with mucinous adenocarcinoma,1patients are diagnosed with clear cell caicinoma,3 patients are diagnosed with endometrial adenocarcinoma.The histological grade is 14 patients can be grouped into G3,while 6 patients are grouped intoG1+G2.Accroding to FIGO stages,there are 5 patients in the group of I~II,and 15 patients in the group of III~IV.2.The analysis in epithelial ovarian cancer patients with DVT compared with ovarian cancer patients without DVT showed that the body mass index(BMI),age,tumor stage,platelet(PLT),prothrombin time(PT)and fibrinogen(FIB)had significant difference(P<0.05).They are connected with the formation of DVT.The analysis in ovarian cancer patients without DVT compared with benign ovarian tumor patients without DVT showed that platelet(PLT),prothrombin time(PT)and fibrinogen(FIB)had significant difference(P<0.05).3.In the DVT group,the median survival time is 33 months,and in the without DVT group,the median survival time is 40 months.The survival in the DVT group were statistically significant lower than those in the epithelial ovarian cancer without DVT group(P<0.05).Conclusions:The FIB,PLT,PT,BMI,age,CA125 are the risk factors of epithelial ovarian cancer with DVT.And the DVT can reduced the median survival time of the epithelial ovarian cancer patient.We should identify the risk factors for high-risk patients and take preventive measures actively to reduce the deep venous thromboembolism,then improve the survival of patients and their prognosis.