Analysis Of Common Pathogens And Drug Resistance In Diabetic Foot Patients With Type 2 Diabetes Mellitus

Diabetic foot ulcer is one of the most serious complications of diabetes.Surgical resection is used to treat gangrene part and the patient are given effective anti-infection treatment,but wound infection often leads to deterioration of the patient's condition.Diabetic foot are not only caused by endocrine disorders,often accompanied by a variety of organ dysfunction or damage,therefore,the use of anti-infective drugs to treat diabetic foot must be reasonable and standard,in order to prevent the deterioration of the disease which caused by the use of drugs.Objective: To investigate the characteristics of pathogens and drug resistance in patients with diabetic foot infection in hospital.Methods: 125 cases of diabetic foot patients hospitalized in hospital from January 2014 to December 2015 were selected as the research object.Before the use of antibiotics after the patient was hospitalized,a small aseptic cotton swab was used to wipe the wound slightly,and the ulcer secretions or pus were collected and placed in a pre-prepared sterilizing test tube.The samples were sent to the laboratory for bacterial culture and drug sensitivity test in 1 hour.According to the manual of clinical medicine,the bacterial culture and drug sensitivity test were carried out by the experimental system including VITEK-2 identification system,auxiliary reagent and drug sensitive card produced by Bio Me Rieux company.Results: 1)119 strains of pathogenic bacteria were isolated,including 68 strains(57.14%)of gram negative bacilli,41 strains(34.45%)of gram positive bacteria and 10 strains(8.40%)of fungi.The most common pathogenic bacteria causing diabetic foot infection were Staphylococcus aureus(17.65%),Enterococcus(14.29%),Pseudomonas aeruginosa(11.76%),Escherichia coli(10.92%),Proteus bacteria(10.92%)and other pneumonia gram Klebsiella,Enterobacter cloacae,Organelles coli Acinetobacter baumannii bacillus,Streptococcus viridans.24 cases were mixed infection,accounting for 19.2%.2)Drug resistance rate is less than 6%.The resistant rate to tetracycline,compound slfamethoxazole tablets,teicacillin and gentamicin was higher,and the total drug resistance rate was more than 40%.Gram positive bacteria are more sensitive to ampicillin/sulbactam and moxifloxacin,and the drug resistance rate is below 10%,but the resistance to penicillin G,oxacillin,aminoglycosides,macrolide antibiotics,tetracyclines,and sulfonamides have high drug resistance.Of particular note is that a certain drug resistance rate to vancomycin and teicoplanin in 12-18%.Conclusion:(1)The infection of ulcer wound in diabetic foot patients is mainly caused by Gram-negative bacteria,followed by Gram positive bacteria.Because of the fact that anaerobic culture was not carried out in this experiment,the data were not given.(2)The resistance rate of G+ bacteria to drugs(ampicillin/sulbactam)and quinolones(ampicillin)and quinolones(moxifloxacin)is low.(3)G-bacteria have high sensitivity to meropenem and imipenem and can be used as the first choice for diabetic foot infection.(4)In order to effectively control the infection of diabetic foot and reduce the occurrence of bacterial resistance,timely and repeated bacterial culture and drug sensitivity tests should be carried out and rational use of antibiotics should be made.