Clinical Diagnosis And Analysis Of Persistent Fifth Aortic Arch

Objective:To summarize the clinical data,imaging feature,clinical treatment and prognosis of 10 cases of persistent fifth aortic arch(PFAA)to improve comprehension of the affliction and reduce its misdiagnosis..Methods:10 suspected cases of PFAA,which were admitted from January 2012 to February 2017 to the Children's Hospital of Chongqing Medical University,were included to collect their general clinical data,laboratory data,imaging data,operation data and chromosome analysis with fluorescence in-situ hybridization(FISH)detection.Results:The median age of 10 suspected PFAA children was 6.5months,the minimum age was twelve days,the maximum age was eleven years old,The average birth weight was 2.875±0.61 kg and all the patients were born at full-term,the ratio between the male and female was 7:3.According to Weinberg's classification,two cases(20%)belonged to type A,six cases(60%)belonged to type B,and two cases(20%)belonged to type C.Two patients and their parents who received FISH analysis did not have the 22q11.2 chromosome deletion.Four patients(40%)receivedsurgery,and their clinical symptoms were improved significantly without restenosis of the descending aorta or the main pulmonary artery after surgery.Conclusion:The onset age of children with PFAA was younger.The incidence rate of male was higher than that of female.The clinical manifestation of PFAA was not typical,and its diagnosis mainly depended on medical imaging.It was feasible to diagnose PFAA combined with echocardiography and computed tomography angiography(CTA).It's treatment depend on surgery,and the relatively long-term curative effects of PFAA were satisfactory.