The Application Value Of Dynamic Contrast-Enhanced MRI In Diabetic Foot Osteomyelitis

ObjectiveTo investigate the application value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in diabetic foot osteomyelitis and its correlation with clinical laboratory examination CRP and ESR.MethodsThirty patients with the clinical comprehensive diagnosis of DF osteomyelitis underwent laboratory examination,conventional MRI and DCE-MRI.Quantitative parameters including the volume transfer constant(Ktrans),rate constant(Kep),extravascular extracellular volume fraction(Ve)of diabetic foot osteomyelitis regions and non-osteomyelitis regions were derived from DCE-MRI data,quantitative parameters between the two regions were analyzed by using Student t test.The Relationship between quantitative parameters and ESR and CRP were analyzed by using correlation analysis.We also used the the receiver operating characteristic curve to analyse the identification ability of Ktrans?Kep?Ve in osteomyelitis and non-osteomyelitis regions.ResultsThe quantitative parameters Ktrans?Kep,and Ve of the osteomyelitis regions are 0.819 ±1.172 ml/min,1.191 ± 0.853 ml/min,0.483 ± 0.328 ml/min,0.101 ±0.054ml/min respectively.The quantitative parameters in osteomyelitis regions were significantly higher than that in non-osteomyelitis region.Pearson correlation analysis showed that Ktrans?Kep?Ve were correlated with CRP and ESR.The ROC analysis showed that Ktrans and Ve are better than Kep for the diagnosis of diabetic foot osteomyelitis.ConclusionThe parameters of DCE-MRI can quantitative evaluate the inflammation degree of osteomyelitis in the diabetic foot,and it has great value in monitoring and evaluating the disease prognosis.