Association Between Vasoactive-inotropic Score And Prognosis In Children With Septic Shock

Objective: To investigate the association between vasoactiveinotropic score(VIS)and prognosis in children with septic shock.Methods: A total of 117 children with decompensated septic shock who received the treatment with vasoactive agents were enrolled.According to their prognosis,they were divided into death group with 41 children and survival group with 76 children.With the maximum VIS within the frst 24 hours(24hVISmax)as the cut-off value(29.5),the children were divided into low VIS group with 78 children and high VIS group with 39 children.The 24 hVISmax and the mean VIS within the frst24 hours(24hVISmean)were calculated for all children.A receiver operating characteristic(ROC)curve analysis was performed for the association between VIS and the prognosis of septic shock.And the logistic regression analyses were performed to assess the independent predictor of mortality in children with septic shock.Results: 1.Compared with the survival group,the death group hadsignificantly higher 24 hVISmax,24hVISmean,PRISM III score,and level of lactate before the use of vasoactive agents and after 24 hours of use(P<0.05).2.24 hVISmax,24hVISmean,PRISM III score,level of lactate before the use of vasoactive agents and after 24 hours of use,and 24-hour pH had a certain value in predicting the prognosis of septic shock,but24 hVISmax had the largest area under the ROC curve.3.24 hVISmax ?29.5was the independent predictor of mortality in children with septic shock(P=0.00).4.Compared with the low VIS group,the high VIS group had significantly higher number of deaths,PRISM III score,and level of lactate before treatment and after 24 hours of treatment(P<0.05).Conclusions: VIS is associated with the mortality of children with septic shock,and the severity and mortality of patients increase with the increase in VIS.