Novel Biomarkers In Early Diagnosis Of Acute Kidney Injury:Where Are We Today

AKI is one of most common critical conditions and is associated with high morbidity and mortality in several clinical areas.The incidence is increasing year by year,7% of all inpatients and 30% of intensive care unit patients are currently affected by AKI.Traditional AKI markers are urine output and blood creatinine,but the value of these is limited nowadays.The process of acute kidney injury and prediction of AKI cannot be detected as early as possible.Early detection of acute renal injury and patients with acute renal injury risk and early treatment can significantly improve the outcomes of these patients.Therefore,with the development of proteomics and metabolomics,the novel biomarkers are gradually entering the research and clinical vision as a powerful diagnostic tool for predicting early acute renal injury.In some studies,the new biomarkers may have higher sensitivity and specificity in the diagnosis and prediction of AKI,which may indicate the occurrence of acute kidney injury earlier than traditional markers.Replacing traditional markers with new biomarkers may be the future.