Effects Of Midazolam On The Electroencephalogram In Patients Undergoing Neurosurgical Surgery

Objective: To observe the effect of midazolam on the electroencephalogram(EEG)of patients under the awaken state and intraoperative anesthesia.Methods: 40 cases with neurosurgical surgery were randomly divided into awaken state group(group I n=20)and intraoperative anesthesia(group II n=20),no limit of gender,20-60 years old,ASA I or II grade,weighting 45-80 kg.Then both groups received intravenously injected midazolam 0.05mg/kg.The data of hemodynamic parameters and EEG in different time point(1minute prior administration T0 and after 1min,2min,3min,5min,10 min,T1-5)were collected and analyzed.Results:1.There was no significant difference between the general conditions of two groups(P>0.05).2.Comparison of EEG changes between two groups of patients: there was a significantly statistical difference in the changes of EEG burst suppression between the two groups.3.The compare hemodynamic parameters in the two groupsAfter midazolam 0.05mg/kg intravenously injected,there was significant in MAP and HR between two groups in different time points(F=7.464,P<0.001;F=3.323,P=0.024),whereas SPO2 has no differences(F=2.152,P>0.05).Time*group interaction was not significant(F=0.213,P>0.05).In the patients under the condition of wakefulness(group I)and under anesthesia(group II),MAP showed a tendency to descent,at T0 time,MAP was higher than that at T1-T5(T0 vs T1:P=0.041;T2:P=0.091;T3: P=0.011T4:P=0.002;T5:P<0.001)within groups.There was no significant difference between the two groups of HR and SPO2 in each time point within groupsrespectively(P > 0.05).Conclusions: After midazolam 0.05mg/kg intravenously injected,there was no obvious change in the electroencephalogram of the patients under awaken state;whereas,the burst suppression of EEG in intraoperative anesthesia groups changed significantly.This result suggested that midazolam must be administered carefully in neurosurgical operation under neuroelectrophysiological monitoring.