Comparison Of Anesthetic Effects Of Different Doses Of Propofol Combined With Sufentanil In Non-intubation Endoscopic Surgery

Objective:To study the effect of intravenous anesthesia with different doses of propofol on CO₂ in patients undergoing non-intubation endoscopic surgery,and to findout the optimal maintenance concentration of propofol,which has the least effect on CO₂.Methods:We included sixty patients undergoing painless gastroenteroscopy,they were randomly divided into three groups according to the maintenance concentration of propofol:group A(5mg/kg?h^-1),group B(7.5mg/kg?h^-1),group C(10mg/kg?h^-1).We monitored mean arterial pressure?MAP?,heart rate?HR?,oxygen saturation?SPO₂?,Transdermal partial pressure of carbon dioxide?tcpCO₂?,transdermal partial pressure of oxygen?tcpO₂?before induction?T0?,after induction 5min?T1?,after induction 10min?T2?,after induction 15min?T3?.Results:In group A,there were 5 patients with limb motility.One case of limb movement and one case of SpO₂ decrease in group B.In group C,there were 6 cases of severe carbon dioxide rise and 2 case of hypotension.Compare with group A and B,tcpCO₂ at T2,T3 was increased significantly?P<0.05?in group C.TcpO₂ at T1,T2,T3was increased significantly?P<0.05?in group B.Conclusion:Propofol sustained infusion of 7.5mg/kg?h^-1 had the least effect on carbon dioxide and was more suitable for anesthesia of non-intubation endoscopy outpatients.