Estimated Value Of Several Serum Markers On Severity Of Acute Pulmonary Embolism

Objective:To investigate the value of Alveolar-Arterial Oxygen Gradient(P(A-a)O2),Blood lactate,C-reactive protein(CRP),Platelet-Lymphocyte Ratio(PLR)and Neutrophil-Lymphocyte Ratio(NLR)level on severity of illness and short-term mortality risk of patients with acute pulmonary embolism.Methods:From January 2014 to October 2017,a total of 206 patients with acute pulmonary embolism were selected in the Department of Respiratory Medicine,Sheng jing Hospital Affiliated to China Medical University,and they were divided into low-risk group(77),moderate-risk group(108)and high-risk group(21)according to criteria for risk stratification in the chinese expert consensus on the diagnosis and treatment of acute pulmonary embolism,and were divided into survivor group(199)and death group(7)according to the short-term prognosis.The levels of CRP,NLR,PLR,P(A-a)O2 and blood lactate were analysed.Results:The levels of CRP,P(A-a)O2 and blood lactate were much higher in high-risk group and moderate-risk group than low-risk group.The levels of CRP,P(A-a)O2 and blood lactate in high-risk group were also much higher than moderate-risk group,and the difference was statistically significant(P<0.01).The levels of NLR and PLR were much higher in high-risk group than moderate-risk group and low-risk group.The levels of NLR?PLR in moderate-risk group was not higher than low-risk group.The levels of CRP,NLR and P(A-a)O2 were much higher in death group than survivor group(P<0.05).Although the levels of PLR and blood lactate were much higher in death group than survivor group.The difference was no statistically significant.Conclusion: Measurements of CRP,NLR,PLR,P(A-a)O2 and blood lactate in acute pulmonary embolism patients are help to evaluate severity of patient's status and prognosis,and guide the clinical judgment and treatment.