| Objective: To investigate the relationship between fibrinogen(Fg)level and clinical stage(TNM stage)in patients with prostate cancer(PCa)and to discuss the significance of monitoring fibrinogen and clinical staging of prostate cancer before treatment.Methods: A retrospective analysis from January 2015 to May 2016 in the First Affiliated Hospital of China Medical University and through the PSA or imaging abnormalities,suspected prostate cancer diagnosed in parallel prostate biopsy or surgical treatment of primary prostate hyperplasia Postoperative pathological diagnosis of prostate cancer patients,and such patients meet(1)without other primary malignant tumors(2)without infection,blood diseases,liver and spleen dysfunction patients(3)no surgery treatment,castration,radiotherapy,endocrine therapy in other hospitals(4)with perfect inpatient medical records(5)without thrombosis,bleeding disorders,unused affect blood coagulation Patient of medicine.A total of 97 cases.The clinical data were collected: age,Fg level,PSA,Gleason score,TNM stage.(Data missing items do not fill without any treatment).The patients were divided into two groups,the I and II of the TNM staging were grouped as a group(low clinical staging group).The tumors in this group were only confined to the prostate capsule.The third and fourth trimesters were grouped into three groups(high staging),This group of patients with prominent prostate tumor capsule or metastasis,and then statistics.And PSA data into an orderly classification count data.Univariate analysis of suspicious risk factors,and then the single factor analysis of suspicious risk factors as independent variables continue to logistic binary regression analysis,the PCa clinical malignant staging independent risk factors.Results: From the results of univariate analysis,it can be concluded that there are significant differences in Fg,Gleason score and PSA between the high clinical stage group and the low clinical stage group,so these indexes may be the suspicious influential factors of the clinical stage of the prostate cancer.However,age can be directly determined not to be a risk factor for the clinical stage of prostate cancer.Fg,Gleason score,PSA bivariate logistic regression analysis as independent variables,it can be drawn Fg,PSA level is an independent risk factor for clinical staging of PCa,respectively,P <0.05;Gleason not score and clinical stage PCa level independent risk factors,P> 0.05.Conclusion: Fg is an independent risk factor for clinical stage of PCa.The level of Fg in patients newly diagnosed with PCa can well reflect the clinical stage of tumor.When the level of Fg is lower,it often indicates that the clinical stage is earlier.When Fg high level reminds clinicians that the patient’s clinical stag may be late.PSA is an independent risk factor for the clinical stage of PCa.The higher the PSA level,the later the clinical stage,the greater the risk of metastasis.Gleason score is a suspicious factor in the clinical stage of PCa,but not an independent factor. |
