Effects Of Zi Chong Granule And Qiong Yu Bao Chun Ointment In Premature Ovarian Failure On The Efficacy Of Targeted Area

Objective:Based on the infrared medical imaging technology to study the characteristicsof reproductive related location in POI(premature ovarian insufficiency,POI),explore the efficacy of ZCG(Zi Chong Granule,ZCG)and QYBCO(Qiong Yu Bao Chun Ointment,QYBCO)on the clinical reproductive targetsinPOI.Method:1.The diagnostic criteria for POI refers to the suggestion of “2016 European human reproductive and Embryology Association”(age<40 years,menstrual abnormalities(oligomenorrhea or menopause)>4 months,FSH>25 U/L).While the standard of normal persons refers to the 10 health standards which was defined by WHO in 2000 and should be conformed to the even constitutional criteria.The information was collected from The patients who were diagnosed as POI from each September to the next February during 2015 and 2017 by the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine and the Second Affiliated Hospital,as well as the normal healthy women under the age of 40 who were examined and been scanned by the infrared thermal imaging(type HIR-2000 or ADT-YL-100 A type)before they ovulation(any day for amenorrhea patients)at the health management center of Chengdu University of Traditional Chinese Medicine.The participants who were interfering the results of this study(the use of sex hormone drugs in the last 3 months,pelvic inflammatory disease and other acute infections in past January,or with cardiovascular disease,liver disease,renal disease,primary hemopoietic disorder)were excluded.Focused on the absolute calorific value and the background calorific value of patients including head and face(Forehead,face,the upper and medium part of the back side head),chest and abdomen(double breast,precardiac region,Ren Channel,ShenQue point,lower abdomen,uterus,double appendage),waist and back(Du Meridian,both sides of kidney region),and limbs(Palms of hands,both sides of feet in front position and back position).2.Bring the patients in(1)who are POI and are inconformity with the standard of kidney essence deficiency syndrome,and had completed the dynamic scan after eating one or two medicine between ZCG(Sichuan green leaf Bao Guang pharmaceutical industry Limited by Share Ltd is entrusted with the investment granules,10 g,37? Warm Water 200 ml dissolving after)and QYBCO(The QYBCO made by the 39 anointment dispensary of the Affiliated Hospital of the Chengdu traditional Chinese MedicineUniversity,20 ml,37 centigrade warm water after 200 ml dissolution)before ovulation(amenorrhea patients can be used for any day)into the experiment group(two kinds of drugs were scanned at intervals of 24 h,and the scanning sequence was random).Bring the women in(1)who are under 40 and drunk 200ml37? water before ovulation into comparation group to take dynamic scan.Participants of Each group completed total body scan for 6 times,before drinking(0min)and after drinking for 30 min,70min,100 min,130min,160 min.The location calorific value measured was the same as(1)3.The collected data were analyzed by Excel and SPSS23.0,the relative heat value of each time point in each location was calculated and the heat value trend was plotted,and the target location of ZCG and QYBCO was observed.4.After 3 menstrual cycles(3 months of amenorrhea for 3 months),the patients were evaluated.The changes of TCM syndrome score,basic FSH,AMH,AFC and other indexes were observed before and after treatment.Results:1.The study included 33 patients with POI,1 cases of primary ovarian insufficiency(3.03%),and 32 cases of secondary ovarian insufficiency(96.97%),with the average age of34.76+4.15 years,the average course of 5.09+3.646 years,33 in the healthy control group,average age 33.30+3.63 years,and there was no difference between the two groups(P > 0.05).2.The 66 participants including 33 cases of POI and 33 healthy childbearing age participants under 40 years,completed the infrared thermal imaging scan,2112 location heat value was measured.The relative heat value of the lower abdominal,uterus,double appendage,both sides of kidney region,left hand palm,both sides of feet in front positionand theright foot in back positiontwas higher than that of the healthy control group.The difference was significant(P < 0.05).The relative heat value of the upper part of the back side head was higher than that of the healthy control group,the difference was significant(P< 0.01).3.The 9 cases of POI with traditional Chinese medicine compound infrared thermal imaging dynamic scan were completed,the minimum age of 28 years,the maximum age of39 years,the average age of 34.33+4.53 years,the shortest course of 3 years,the longest 9years,the average course of 6.11+2.2 years,completed the dynamic scanning of infrared thermal imaging of taking ZCG and QYBCO.In 7 cases,7 healthy controls were performed with warm water infrared thermal imaging,and 16 participants completed 126 systemic scans and observed 22 locations each time.2772 locations were measured and 2310 location heat values were measured repeatedly.4.The participants who took ZCG in the forehead,the face,the double breast,the precardiac region,Ren Channel,ShenQue point,lower abdomen,uterus,double appendage,Du Meridian,both sides of feet in front position,the left foot in back positiont,the heat value approached the healthy control group,the difference was significant(P < 0.05),in both sides of kidney region,the heat value approached the healthy control group,the difference was obvious.The difference is significant(P < 0.01);the participants who took QYBCO in the right breast,the precardiac region,Ren Channel,ShenQue point,uterus,Du Meridian,both sides of kidney region were in 8 locations,the heat value approached the healthy control group,the difference was significant(P < 0.05).In the left appendage location,the heat value approached the healthy control group,the difference was obvious(P<0.01);in the 22 locations measured,the target location of ZCG and QYBCO is the same,and each target location shows that the ZCG is stronger than the QY BCO.5.After the treatment of ZCG,the score of TCM syndrome was decreased in the patients with POI syndrome,the difference was ignificant(P<0.05),the decrease of FSH,the increase of AMH and the number of sinus follicles increased,the difference was not significant(P >0.05).Conclusion:1.Patients with POI have the characteristics of yin deficiency and internal heat,and increased body surface metabolic heat.2.ZCG and QYBCO can reduce the metabolic calorific value in POI patients with yin deficiency and internal heat,and the effect ofZCG is stronger.3.The target location of ZCG is mainly in the forehead,the face,the double breast,the precardiac region,Ren Channel,ShenQue point,lower abdomen,uterus,double appendage,Du Meridian,both sides of kidney region,both sides of feet in front position,the left foot in back positiont.The target location of QYBCO is mainly in the right breast,the precardiac region,Ren Channel,ShenQue point,uterus,the left appendage,Du Meridian,both sides of kidney region.4.ZCG can improve ovarian function through kidney tonifying and essence replenishing,and has certain action on regulating reproductive endocrine.