The Correlation Of Serum CD146 And Cognitive Impairment After Ischemic Stroke

Objective Explore the correlation of serum CD146 and cognitive impairment after ischemic stroke.Methods 118 cases of ischemic stroke hospitalized in neurology,Rehabilitation Department and of our hospital from November 2016 to August 2017 were selected as the case group and in our hospital physical examination center 51 cases as a control group,collected the clinical data of each group.None of the study subjects had cognitive impairment.The case group was followed up for 3 months.According to the Montreal Cognitive Assessment(Mo CA)score,divided into 64 cases of cognitive impairment group,54 cases without cognitive impairment group.The concentration of serum CD146 and serum A?1-42 were determinated by ELISA and compared the differences of serum CD146 concentration of each group;compared the differences of serum A?1-42 concentration of each group.The correlation between serum CD146 and Mo CA was analyzed using Spearman;The correlation between serum CD146 and serum A?1-42 was analyzed using Pearson.The correlation between serum CD146 level and cognitive impairment was analyzed using logistic regression analysis and to analysis the correlation of serum CD146 and cognitive impairment after ischemic stroke.Results(1)The case group was evaluated by Mo CA 3 months after stroke,the incidence of cognitive impairment was 54.24%.(2)Compared with control group,serum CD146 level increased in patients with ischemic stroke [(8.17±2.56)pg/m L vs(7.76±1.12)pg/m L],t=-9.42,P<0.01;Compared with impaired cognition group,serum CD146 level increased in normal cognition group [(10.45±1.72)pg/m L vs(6.24±1.21)pg/m L],t=13.09,P<0.01;Compared with control group,serum A?1-42 level Reduced in patients with ischemic stroke [(111.17±36.11)pg/m L vs(158.02±35.99)pg/m L],t = 74.46,P < 0.01;Compared with impaired cognition group,serum A?1-42 level increased in normal cognition group[(127.94±34.88)pg/m L vs(94.40±37.33)pg/m L],t = 64.52,P<0.01.(3)Spearman correlation analysis showed a positive correlation between serum CD146 levels Mo CA score(r = 0.96,P < 0.01);Pearson correlation analysis showed a positive correlation between serum CD146 levels serum A?1-42 levels(r=0.95,P<0.01).(4)Multivariate logistic regression analysis CD146(OR=0.04,P<0.01)There was a regression relationship with cognitive impairment after stroke;Multivariate logistic regression analysis A?1-42(OR = 0.78,P = 0.08)There was a regression no relationship with cognitive impairment after stroke.Conclusion(1)Low serum CD146 concentration was an independent risk factor for post-ischemic stroke cognitive impairment;Research suggests the importance of interventions in controllable factors such as hypertension and diabetes.(2)Serum CD146 levels were positively correlated with Mo CA values and serum A?1-42 levels;The lower the concentration of serum CD146,the more severe cognitive impairment.(3)Serum CD146 is associated with cognitive impairment after ischemic stroke and can reflect the cognitive function of patients with PSCI;After discussion,serum CD146 can be used as a biomarker of cognitive impairment after ischemic stroke.