Study On The Relationgship Between Serum 25-hydroxyvitamin D₃ And Carotid Atherosclerosis In Diabetic Patients

Objectives:Analyze the risk factors of carotid atherosclerosis and investigate the relationship between 25-hydroxyvitamin D₃ and carotid atherosclerosis in patients with type 2 dia-betes mellitus by analyzing the concentrations of 25-hydroxyvitamin D₃.Methods:In this study,238 clinically diagnosed Type 2 diabetes mellitus patients were divi-ded into two groups which is type 2 diabetes mellitus without carotid atherossclerosis group（Non-CAS group,94 cases）and type 2 diabetes mellitus complicated with caroti-d atherosclerosis group（CAS group,144 cases）according to IMT value of the carotid artery.The general information of patients was collected,including gender、age、dur-ation of diabetes、height、weight、blood pressure and the history of smoking、 hype-rtension and coronary heart disease.Fasting venous blood samples were taken from all patients to estimate their FBG、TC、TG、HDL-C、LDL-C、LPA2、Ca、Insulin、OCN and 25（OH）D₃ by Automatic biochemical analyzer and automatic chemilumine-scence instrument.Statistical analyses were performed using SPSS19.0 Statistics.The variables conforming to normal distribution are expressed in`x±s deviotion and com-parised by t test;conunting dates using chi square test.Analyze the risk factors of caro-tid atherosclerosis and investigate the relationship between 25-hydroxyvitamin D₃ and carotid atherosclerosis in patients with type 2 diabetes mellitus by Logistic regression analysis.Results:（1）The t-test indicates that the age,the duration of diabetes,BMI and the concen-tration of LDL-C、LAP2、Hb A1c、HOMA-IR and OCN in CAS group were sign-ificantly different from the Non-CAS group（P<0.05）,other indices such as SBP、DBP、TC、TG、HDL-C、Ca and FBG levels showed no significant difference（P>0.05）.The Chi square test showed the history of smooking,hypertension and coronary heart disease have significantly different between two groups（P<0.05）.（2）The 25（OH）D₃ status were significantly lower in CAS group compared to Non-CAS by t test（P<0.05）.All patients are divided into groups of vitamin D deficiency and sufficiency with of 25（OH）D₃ equal to 50nmol/L as the cutoff value,results showed that 25（OH）D₃ deficiency patients at risk for cervical atherosclerosis is2.899 times that 25（OH）D₃ deficiency patients.（3）The logistic regression analysis showed that the relationship between25（OH）D₃ and carotid atherosclerosis in type 2 diabetic after adjusting the influence of gender、age and other factors.The hierarchical multiple regression indicated thatwith severe 25（OH）D₃ deficiency were 4.754 times increase odds of being T2 DM with CAS while those with mild to moderate deficiency were 1.535 times increase odds of being T2 DM with CAS.Conclusion:（1）Vitamin D deficiency is prevalent in Type 2 diabetes mellitus,the CAS group patients serum 25（OH）D₃ levels was less than that the Non-CAS groups.（2）With the increase of age、during of disease、HOMA-IR 、LPA2and decreased of OCN level,the risk factors of carotid atherosclerosis are increased in type 2 diabetic patients.（3）The level of serum 25（OH）D₃ in patients with T2 DM was negatively correlat-ed with the levels of TC,LDL and OCN.（4）There is association between 25（OH）D₃ and carotid atherosclerosis in patients with type 2 diabetes mellitus.The level of serum 25（OH）D₃ decreased,the risk of caro-tid atherosclerosis in type 2 diabetic patients increased.