Study On Nano-carbon Tracer On Prognosis Of Patients With Gastric Cancer

Objective:To evaluate the effect of nano-carbon tracer on the prognosis of gastric cancer patients,the survival status of patients with gastric cancer treated with nano-carbon tracer and those without nano-carbon tracer.Methods:1.The clinicopathological and follow-up data of 886 patients with gastric cancer who were hospitalized in Yuzhouding Hospital from 2010 to June 2014 were analyzed retrospectively.484 patients who were treated with nano-carbon tracer during operation were divided into nano-carbon group.402 patients who were not treated with nano-carbon tracer were divided into Non-nano carbon group.The number of lymph nodes,postoperative complications and 3-year survival rate were compared between the two groups.Cox regression model was used to analyze the prognostic factors of patients with gastric cancer.Results:1.The number of lymph nodes detected in nano-carbon group and non-nano-carbon group were 31.99±8.990 and 19.81±4.740 respectively(P < 0.000),and the number of metastatic lymph nodes in nano-carbon group and non-nano-carbon group were 4.87±6.229 and 3.61±4.764 respectively(P < 0.000).The difference between the two groups was statistically significant.2.The 3-year survival rates of nano-carbon group and non-nano-carbon group were66.9% and 57.2%;the postoperative complications of nano-carbon group and non-nano-carbon group were 101(20.87%)and 91(22.63%)(P=0.525).The complications of ano-carbon group were 42 cases of infection,15 cases of anastomotic fistula,3 cases of abdomen bleeding,12 cases of digestive tract obstruction,64 cases of gastric otility disorder,2 cases of duodenal fistula,10 cases of pulmonary infection,7cases of chylous leakage and 6 cases of pancreatic fistula.In the non-nano carbon group,the complications were infection in 33 cases,anastomotic leakage in 9 cases,abdomen bleeding in 9 case,digestive tract obstruction in 7 cases,gastric motility in 6 cases,duodenal fistula in 3 cases,pulmonary infection in 5 cases,chylous leakage in 15 cases,andpancreatic fistula in 4 cases.3.Univariate analysis showed that the application of nano-carbon tracer,tumor size,depth of tumor infiltration,TNM stage and tumor differentiation could influence the prognosis of gastric cancer.Multivariate analysis showed that TNM stage and depth of tumor infiltration.Tumor size and intraoperative application of nano-carbon racer are independent factors affecting prognosis of gastric cancer.Conclusion:The application of nano-carbon tracer can increase the number of lymph nodes and metastatic lymph nodes,and do not increase the incidence of postoperative complications,And it can reduce the complications of abdominal bleeding and chylous leakage.the prognosis of gastric cancer and whether to use nano-carbon tracer,tumor size,depth of tumor infiltration.The degree of differentiation of tumor is related to TNM stage,the depth of tumor invasion,and intraoperative application of nano-carbon tracer are independent factors influencing the prognosis of gastric cancer.Whether the application of nano-carbon tracer as a new index to evaluate the prognosis of gastric cancer needs to be confirmed by a multi-center and large sample clinical study.